Pyrimidinylpiperazine: Difference between revisions
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| IUPAC_name = 2-piperazin-1-ylpyrimidine |
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| Reference = <ref>[http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=421235|ALDRICH&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC 1-(2-Pyrimidyl)piperazine] at [[Sigma-Aldrich]]</ref> |
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| image = pyrimidinylpiperazine.png |
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| ImageSize = 200px |
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| ATC_prefix = |
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| IUPACName = 2-Piperazin-1-yl-pyrimidine |
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| ATC_suffix = |
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| Section1 = {{Chembox Identifiers |
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| DrugBank = |
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| ChemSpiderID = 80080 |
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| chemical_formula = C<sub>8</sub>H<sub>12</sub>N<sub>4</sub> |
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| molecular_weight = 164.21 g/mol |
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| Section2 = {{Chembox Properties |
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| bioavailability = |
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| C=8|H=12|N=4 |
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| protein_bound = |
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| metabolism = |
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| Density = 1.158 g/mL |
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| elimination_half-life = |
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| MeltingPt = |
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| excretion = |
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| BoilingPtC = 277 |
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| Solubility = }} |
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| Section3 = {{Chembox Hazards |
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| routes_of_administration = |
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| MainHazards = Irritant ('''X1''') |
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| FlashPt = 110 °C |
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| Autoignition = |
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| RPhrases = {{R36/37/38}} |
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| SPhrases = {{S26}} {{S36}} |
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'''1-(2-Pyrimidinyl)piperazine''' ('''1-PP''') is a [[psychoactive drug]] and [[research chemical]] of the [[piperazine]] and [[azapirone]] [[chemical class]]es. It acts as an [[α2-adrenergic|α<sub>2</sub>-adrenergic receptor]] [[receptor_antagonist|antagonist]],<ref name="pmid1681447">{{Cite pmid|1681447}}</ref> and as a [[5-HT1A_receptor|5-HT<sub>1A</sub> receptor]] [[partial agonist]] to a much lesser extent.<ref name="pmid12438536">{{Cite pmid|12438536}}</ref> It is not known to have any significant affinity for the [[D2_receptor|D<sub>2</sub> receptor]]. 1-PP is a common [[metabolite]] of [[buspirone]], [[gepirone]], [[ipsapirone]], and [[tandospirone]], but not [[alnespirone]], and likely contributes to their [[side effect]] profiles.<ref name="pmid1681447">{{Cite pmid|1681447}}</ref><ref name="pmid12505530">{{Cite pmid|12505530}}</ref> |
'''1-(2-Pyrimidinyl)piperazine''' ('''1-PP''') is a [[psychoactive drug]] and [[research chemical]] of the [[piperazine]] and [[azapirone]] [[chemical class]]es. It acts as an [[α2-adrenergic|α<sub>2</sub>-adrenergic receptor]] [[receptor_antagonist|antagonist]],<ref name="pmid1681447">{{Cite pmid|1681447}}</ref> and as a [[5-HT1A_receptor|5-HT<sub>1A</sub> receptor]] [[partial agonist]] to a much lesser extent.<ref name="pmid12438536">{{Cite pmid|12438536}}</ref> It is not known to have any significant affinity for the [[D2_receptor|D<sub>2</sub> receptor]]. 1-PP is a common [[metabolite]] of [[buspirone]], [[gepirone]], [[ipsapirone]], and [[tandospirone]], but not [[alnespirone]], and likely contributes to their [[side effect]] profiles.<ref name="pmid1681447">{{Cite pmid|1681447}}</ref><ref name="pmid12505530">{{Cite pmid|12505530}}</ref> |
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== See also == |
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* [[Azapirone]] |
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== References == |
== References == |
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{{Reflist}} |
{{Reflist|2}} |
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{{Adrenergics}} |
{{Adrenergics}} |
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{{DEFAULTSORT:Pyrimidinyl)piperazine, 1-(2-}} |
{{DEFAULTSORT:Pyrimidinyl)piperazine, 1-(2-}} |
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[[Category:Piperazines]] |
[[Category:Piperazines]] |
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[[Category:Pyrimidines]] |
[[Category:Pyrimidines]] |
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{{pharmacology-stub}} |
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Revision as of 02:31, 27 January 2010
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| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.040.107 |
| Chemical and physical data | |
| Formula | C8H12N4 |
| Molar mass | 164.21 g/mol |
| 3D model (JSmol) | |
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1-(2-Pyrimidinyl)piperazine (1-PP) is a psychoactive drug and research chemical of the piperazine and azapirone chemical classes. It acts as an α2-adrenergic receptor antagonist,[1] and as a 5-HT1A receptor partial agonist to a much lesser extent.[2] It is not known to have any significant affinity for the D2 receptor. 1-PP is a common metabolite of buspirone, gepirone, ipsapirone, and tandospirone, but not alnespirone, and likely contributes to their side effect profiles.[1][3]
See also
References
- ^ a b Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 1681447, please use {{cite journal}} with
|pmid=1681447instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 12438536, please use {{cite journal}} with
|pmid=12438536instead. - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 12505530, please use {{cite journal}} with
|pmid=12505530instead.
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