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'''Pentylone''' (β-Keto-Methylbenzodioxolylpentanamine, '''βk-Methyl-K''', '''βk-MBDP''', '''methylenedioxypentedrone''', or 1‐(3,4‐methylenedioxyphenyl)‐2‐(methylamino)pentan‐1‐one<ref name=pmid21960541/>) is a [[stimulant]] developed in the 1960s.<ref>Substituted phenyl-α-amino ketones. British Patent GB 1085135 (1969).</ref> It is a [[substituted cathinone]] (a type of [[substituted phenethylamine]]). It has been identified in some samples of powders sold as "NRG-1", along with varying blends of other cathinone derivatives including [[flephedrone]], [[3',4'-Methylenedioxy-α-pyrrolidinobutiophenone|MDPBP]], [[Methylenedioxypyrovalerone|MDPV]] and [[4'-Methyl-α-pyrrolidinopropiophenone|4-MePPP]].
'''Pentylone''' (<span style="word-break:break-all;">β-Keto-Methylbenzodioxolylpentanamine</span>, '''βk-Methyl-K''', '''βk-MBDP''', '''methylenedioxypentedrone''', or 1‐(3,4‐methylenedioxyphenyl)‐2‐(methylamino)pentan‐1‐one<ref name=pmid21960541/>) is a [[stimulant]] developed in the 1960s.<ref>Substituted phenyl-α-amino ketones. British Patent GB 1085135 (1969).</ref> It is a [[substituted cathinone]] (a type of [[substituted phenethylamine]]). It has been identified in some samples of powders sold as "NRG-1", along with varying blends of other cathinone derivatives including [[flephedrone]], [[3',4'-Methylenedioxy-α-pyrrolidinobutiophenone|MDPBP]], [[Methylenedioxypyrovalerone|MDPV]] and [[4'-Methyl-α-pyrrolidinopropiophenone|4-MePPP]].
It was also found in combination with 4-MePPP being sold as "NRG-3".<ref name="pmid21960541">{{cite journal |vauthors=Brandt SD, Freeman S, Sumnall HR, Measham F, Cole J |title=Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones |journal=Drug Testing and Analysis |volume= 3|issue= 9|pages= 569–75|date=December 2010 |pmid=21960541 |doi=10.1002/dta.204 |url=}}</ref> Reports indicate side effects include feelings of paranoia, agitation and inability to sleep, with effects lasting for several days at high doses.<ref>{{cite journal |last1=Joe Bish |title=Watch Out for Pentylone, the Horrible New MDMA Additive |journal=Vice |date=Aug 4, 2017 |url=https://www.vice.com/en_uk/article/pagjxg/watch-out-for-pentylone-the-horrible-new-mdma-additive}}</ref>
It was also found in combination with 4-MePPP being sold as "NRG-3".<ref name="pmid21960541">{{cite journal |vauthors=Brandt SD, Freeman S, Sumnall HR, Measham F, Cole J |title=Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones |journal=Drug Testing and Analysis |volume= 3|issue= 9|pages= 569–75|date=December 2010 |pmid=21960541 |doi=10.1002/dta.204 |url=}}</ref> Reports indicate side effects include feelings of paranoia, agitation and inability to sleep, with effects lasting for several days at high doses.<ref>{{cite journal |last1=Joe Bish |title=Watch Out for Pentylone, the Horrible New MDMA Additive |journal=Vice |date=Aug 4, 2017 |url=https://www.vice.com/en_uk/article/pagjxg/watch-out-for-pentylone-the-horrible-new-mdma-additive}}</ref>



Revision as of 09:41, 21 July 2018

Pentylone
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
  • (±)-1-(1,3-benzodioxol-5-yl)-2-(methylamino)pentan-1-one
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H17NO3
Molar mass235.278 g/mol g·mol−1
3D model (JSmol)
  • c2cc1OCOc1cc2C(=O)C(NC)CCC
  • InChI=1S/C13H17NO3/c1-3-4-10(14-2)13(15)9-5-6-11-12(7-9)17-8-16-11/h5-7,10,14H,3-4,8H2,1-2H3 ☒N
  • Key:DFMLULIEUUXXSA-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Pentylone (β-Keto-Methylbenzodioxolylpentanamine, βk-Methyl-K, βk-MBDP, methylenedioxypentedrone, or 1‐(3,4‐methylenedioxyphenyl)‐2‐(methylamino)pentan‐1‐one[1]) is a stimulant developed in the 1960s.[2] It is a substituted cathinone (a type of substituted phenethylamine). It has been identified in some samples of powders sold as "NRG-1", along with varying blends of other cathinone derivatives including flephedrone, MDPBP, MDPV and 4-MePPP. It was also found in combination with 4-MePPP being sold as "NRG-3".[1] Reports indicate side effects include feelings of paranoia, agitation and inability to sleep, with effects lasting for several days at high doses.[3]

Pharmacology

Pentylone acts as a serotonin-norepinephrine-dopamine reuptake inhibitor and a serotonin releasing agent.[4]

Legality

Pentylone is banned in Canada, Germany, Sweden and also in the United States and in the UK.[5][6]

See also

References

  1. ^ a b Brandt SD, Freeman S, Sumnall HR, Measham F, Cole J (December 2010). "Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones". Drug Testing and Analysis. 3 (9): 569–75. doi:10.1002/dta.204. PMID 21960541.
  2. ^ Substituted phenyl-α-amino ketones. British Patent GB 1085135 (1969).
  3. ^ Joe Bish (Aug 4, 2017). "Watch Out for Pentylone, the Horrible New MDMA Additive". Vice.
  4. ^ Simmler, L. D.; Rickli, A.; Hoener, M. C.; Liechti, M. E. (2014). "Monoamine transporter and receptor interaction profiles of a new series of designer cathinones". Neuropharmacology. 79: 152–60. doi:10.1016/j.neuropharm.2013.11.008. PMID 24275046.
  5. ^ "Cannabinoider föreslås bli klassade som hälsofarlig vara" (in Swedish). Retrieved 29 June 2015.
  6. ^ Schedules of Controlled Substances: Temporary Placement of 10 Synthetic Cathinones Into Schedule I