'''Brompheniramine''' ('''Bromfed''', '''Dimetapp''', '''Bromfenex''', '''Dimetane''', '''BPN''', '''Lodrane'''), commonly marketed as its salt '''brompheniramine [[maleate]]''' is an [[antihistamine]] drug of the [[propylamine]] (alkylamine) class. It is readily available [[Over-the-counter drug|over the counter]] and is indicated for the treatment of the symptoms of the [[common cold]] and [[allergic rhinitis]], such as runny nose, itchy eyes, watery eyes, and sneezing. It is a first-generation antihistamine.
'''Brompheniramine''' ('''Bromfed''', '''Dimetapp''', '''Bromfenex''', '''Dimetane''', '''BPN''', '''Lodrane'''), commonly marketed as its salt '''brompheniramine [[maleate]]''', is an [[antihistamine]] drug of the [[propylamine]] (alkylamine) class. It is readily available [[Over-the-counter drug|over the counter]] and is indicated for the treatment of the symptoms of the [[common cold]] and [[allergic rhinitis]], such as runny nose, itchy eyes, watery eyes, and sneezing. It is a first-generation antihistamine.
Brompheniramine is part of a series of antihistamines including [[pheniramine]] (Naphcon) and its halogenated derivatives and others including [[fluorpheniramine]], [[chlorpheniramine]], [[dexchlorpheniramine]] (Polaramine), [[deschlorpheniramine]], dipheniramine (also known as [[triprolidine]] with the trade name Actifed), and iodopheniramine.
Brompheniramine is part of a series of antihistamines including [[pheniramine]] (Naphcon) and its halogenated derivatives and others including [[fluorpheniramine]], [[chlorpheniramine]], [[dexchlorpheniramine]] (Polaramine), [[deschlorpheniramine]], dipheniramine (also known as [[triprolidine]] with the trade name Actifed), and iodopheniramine.
Brompheniramine (Bromfed, Dimetapp, Bromfenex, Dimetane, BPN, Lodrane), commonly marketed as its salt brompheniramine maleate, is an antihistamine drug of the propylamine (alkylamine) class. It is readily available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. It is a first-generation antihistamine.
The halogenated alkylamine antihistamines all exhibit optical isomerism and brompheniramine products contain racemic brompheniramine maleate whereas dexbrompheniramine (Drixoral) is the dextrorotary (right-handed) stereoisomer.
Like other agents of this type, brompheniramine also has analgesic-sparing (potentiating) effects on opioid analgesics, commonly reducing codeine, dihydrocodeine, and hydrocodone requirements by 10 to 35 percent.
The halogenated alkylamine antihistamines all exhibit optic isomerism and brompheniramine products contain racaemic brompheniramine maleate whereas dexbrompheniramine(Drixoral) is the dextrorotary (right-handed) stereoisomer.
Side effects
Its effects on the cholinergic system may include side-effects such as drowsiness, sedation, dry mouth, dry throat, blurred vision, and increased heart rate.
Chemistry
Brompheniramine, 3-(p-bromophenyl)-3-(2-pyridyl)propyldimethylamine, is an analog of chlorpheniramine. The only difference is that the chlorine atom in the benzene ring is replaced with a bromine atom. It is also synthesized in an analogous manner.
^Barondes, Samuel H. (2003). Better Than Prozac. New York: Oxford University Press. pp. 39–40. ISBN0-19-515130-5. {{cite book}}: Cite has empty unknown parameter: |month= (help)
