HZ-2

HZ-2
Identifiers
	IUPAC name Dimethyl 3,7-dimethyl-9-oxo-2,4-dipyridin-2-yl-3,7-diazabicyclo[3.3.1]nonane-1,5-dicarboxylate;
CAS Number	253304-60-8;
PubChem CID	356604;
CompTox Dashboard (EPA)	DTXSID90326741 ;
Chemical and physical data
Formula	C23H26N4O5
Molar mass	438.475 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES n3ccccc3C(N1C)C2(C(=O)OC)CN(C)CC(C2=O)(C(=O)OC)C1c4ccccn4;
	(verify)

HZ-2 is a drug which acts as a highly selective κ-opioid agonist.^[1] It is a potent analgesic with around the same potency as morphine, with a long duration of action and high oral bioavailability.^[2]^[3] Side effects include sedation, nausea and dysphoria as well as diuretic effects.^[4]

References

^ Siener, T; Cambareri, A; Kuhl, U; Englberger, W; Haurand, M; Kögel, B; Holzgrabe, U (2000). "Synthesis and opioid receptor affinity of a series of 2, 4-diaryl-substituted 3,7-diazabicylononanones". Journal of Medicinal Chemistry. 43 (20): 3746–51. doi:10.1021/jm0009484. PMID 11020289.
^ Holzgrabe, U; Cambareri, A; Kuhl, U; Siener, T; Brandt, W; Strassburger, W; Friderichs, E; Englberger, W; et al. (2002). "Diazabicyclononanones, a potent class of kappa opioid analgesics". Farmaco. 57 (7): 531–4. doi:10.1016/s0014-827x(02)01243-0. PMID 12164207.
^ Holzgrabe, U; Brandt, W (2003). "Mechanism of action of the diazabicyclononanone-type kappa-agonists". Journal of Medicinal Chemistry. 46 (8): 1383–9. doi:10.1021/jm0210360. PMID 12672238.
^ Kögel, B; Christoph, T; Friderichs, E; Hennies, HH; Matthiesen, T; Schneider, J; Holzgrabe, U. (1998). "HZ2, a Selective Kappa-Opioid Agonist". CNS Drug Reviews. 4 (1): 54–70. doi:10.1111/j.1527-3458.1998.tb00041.x.

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