MAP2K2

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MAP2K2
Protein MAP2K2 PDB 1s9i.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2, mitogen-activated protein kinase kinase 2
External IDs MGI: 1346867 HomoloGene: 48591 GeneCards: MAP2K2
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for MAP2K2
Genomic location for MAP2K2
Band 19p13.3 Start 4,090,321 bp[1]
End 4,124,129 bp[1]
RNA expression pattern
PBB GE MAP2K2 213490 s at fs.png

PBB GE MAP2K2 202424 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030662

NM_023138
NM_001347144

RefSeq (protein)

NP_109587

NP_001334073
NP_075627

Location (UCSC) Chr 19: 4.09 – 4.12 Mb Chr 19: 81.11 – 81.13 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene.[5] It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2. [6]

Function[edit]

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1.

The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.

The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.[7]

Interactions[edit]

MAP2K2 has been shown to interact with MAPK3[8][9][10] and ARAF.[11]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126934 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035027 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem. 268 (15): 11435–9. PMID 8388392. 
  6. ^ "MAP2K2 mitogen-activated protein kinase kinase 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2015-10-16. 
  7. ^ "Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2". 
  8. ^ Marti, A; Luo Z; Cunningham C; Ohta Y; Hartwig J; Stossel T P; Kyriakis J M; Avruch J (Jan 1997). "Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. UNITED STATES. 272 (5): 2620–8. doi:10.1074/jbc.272.5.2620. ISSN 0021-9258. PMID 9006895. 
  9. ^ Butch, E R; Guan K L (Feb 1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2". J. Biol. Chem. UNITED STATES. 271 (8): 4230–5. doi:10.1074/jbc.271.8.4230. ISSN 0021-9258. PMID 8626767. 
  10. ^ Zheng, C F; Guan K L (Nov 1993). "Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases". J. Biol. Chem. UNITED STATES. 268 (32): 23933–9. ISSN 0021-9258. PMID 8226933. 
  11. ^ Yin, Xiang L; Chen She; Yan Jun; Hu Yun; Gu Jian X (Feb 2002). "Identification of interaction between MEK2 and A-Raf-1". Biochim. Biophys. Acta. Netherlands. 1589 (1): 71–6. doi:10.1016/S0167-4889(01)00188-4. ISSN 0006-3002. PMID 11909642. 

Further reading[edit]

External links[edit]