AKT2

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AKT2
Protein AKT2 PDB 1gzk.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAKT2, v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, AKT serine/threonine kinase 2
External IDsMGI: 104874 HomoloGene: 48773 GeneCards: AKT2
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for AKT2
Genomic location for AKT2
Band19q13.2Start40,230,317 bp[1]
End40,285,536 bp[1]
RNA expression pattern
PBB GE AKT2 211453 s at fs.png

PBB GE AKT2 203809 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243027
NM_001243028
NM_001626
NM_001330511

NM_001110208
NM_007434
NM_001331108
NM_001331109

RefSeq (protein)

NP_001229956
NP_001229957
NP_001317440
NP_001617

NP_001103678
NP_001318037
NP_001318038
NP_031460

Location (UCSC)Chr 19: 40.23 – 40.29 MbChr 7: 27.59 – 27.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene.[5]

Function[edit]

This gene is a putative oncogene encoding a protein belonging to the AKT subfamily of serine/threonine kinases that contain SH2-like (Src homology 2-like) domains. The encoded protein is a general protein kinase capable of phosphorylating several known proteins.[6]

Clinical significance[edit]

The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers.[6]

Mice lacking Akt2 have a normal body mass, but display a profound diabetic phenotype, indicating that Akt2 plays a key role in signal transduction downstream of the insulin receptor. Mice lacking Akt2 show worse outcome in breast cancer initiated by the large T antigen as well as the neu oncogene.[7]

Interactions[edit]

AKT2 has been shown to interact with:

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105221 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004056 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR (November 1992). "AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas". Proc Natl Acad Sci U S A. 89 (19): 9267–71. doi:10.1073/pnas.89.19.9267. PMC 50107Freely accessible. PMID 1409633. 
  6. ^ a b "Entrez Gene: AKT2 v-akt murine thymoma viral oncogene homolog 2". 
  7. ^ Heron-Milhavet L, Khouya N, Fernandez A, Lamb NJ (2011). "Akt1 and Akt2: differentiating the aktion". Histol. Histopathol. 26 (5): 651–62. PMID 21432781. 
  8. ^ Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR (September 1999). "Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2". Oncogene. 18 (35): 4891–8. doi:10.1038/sj.onc.1203080. PMID 10490823. 
  9. ^ Yuan ZQ, Feldman RI, Sun M, Olashaw NE, Coppola D, Sussman GE, Shelley SA, Nicosia SV, Cheng JQ (August 2002). "Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells". J. Biol. Chem. 277 (33): 29973–82. doi:10.1074/jbc.M203636200. PMID 12048203. 
  10. ^ Figueroa C, Tarras S, Taylor J, Vojtek AB (November 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284. 
  11. ^ Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444. 
  12. ^ Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986. 

Further reading[edit]

External links[edit]