GRK5

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GRK5
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GRK5, GPRK5, G protein-coupled receptor kinase 5
External IDs MGI: 109161 HomoloGene: 3879 GeneCards: 2869
Genetically Related Diseases
Disease Name References
diabetes mellitus type 2
RNA expression pattern
PBB GE GRK5 204395 s at tn.png

PBB GE GRK5 204396 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005308

NM_018869

RefSeq (protein)

NP_005299.1

NP_061357.3

Location (UCSC) Chr 10: 119.21 – 119.46 Mb Chr 19: 60.89 – 61.09 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

G protein-coupled receptor kinase 5 is an enzyme that in humans is encoded by the GRK5 gene.[1][2]

Function[edit]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).[2]

References[edit]

  1. ^ Kunapuli P, Benovic JL (Jun 1993). "Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family". Proceedings of the National Academy of Sciences of the United States of America 90 (12): 5588–92. doi:10.1073/pnas.90.12.5588. PMC 46766. PMID 7685906. 
  2. ^ a b "Entrez Gene: GRK5 G protein-coupled receptor kinase 5". 

Further reading[edit]

  • Komolov KE, Bhardwaj A, Benovic JL (Aug 2015). "Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases". The Journal of Biological Chemistry 290 (34): 20629–47. doi:10.1074/jbc.M115.647297. PMID 26032409. 
  • Bullrich F, Druck T, Kunapuli P, Gomez J, Gripp KW, Schlegelberger B, Lasota J, Aronson M, Cannizzaro LA, Huebner K (1995). "Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6". Cytogenetics and Cell Genetics 70 (3-4): 250–4. doi:10.1159/000134045. PMID 7789183. 
  • Kunapuli P, Gurevich VV, Benovic JL (Apr 1994). "Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5". The Journal of Biological Chemistry 269 (14): 10209–12. PMID 8144599. 
  • Kunapuli P, Onorato JJ, Hosey MM, Benovic JL (Jan 1994). "Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5". The Journal of Biological Chemistry 269 (2): 1099–105. PMID 8288567. 
  • Nagayama Y, Tanaka K, Hara T, Namba H, Yamashita S, Taniyama K, Niwa M (Apr 1996). "Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor". The Journal of Biological Chemistry 271 (17): 10143–8. doi:10.1074/jbc.271.17.10143. PMID 8626574. 
  • Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ (May 1996). "Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C". The Journal of Biological Chemistry 271 (22): 13266–72. doi:10.1074/jbc.271.22.13266. PMID 8662816. 
  • Fredericks ZL, Pitcher JA, Lefkowitz RJ (Jun 1996). "Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor". The Journal of Biological Chemistry 271 (23): 13796–803. doi:10.1074/jbc.271.23.13796. PMID 8662852. 
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Pronin AN, Carman CV, Benovic JL (Nov 1998). "Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation". The Journal of Biological Chemistry 273 (47): 31510–8. doi:10.1074/jbc.273.47.31510. PMID 9813065. 
  • Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton WA, Moss J, Vaughan M, Lefkowitz RJ (Nov 1998). "beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proceedings of the National Academy of Sciences of the United States of America 95 (24): 14082–7. doi:10.1073/pnas.95.24.14082. PMC 24330. PMID 9826657. 
  • Carman CV, Lisanti MP, Benovic JL (Mar 1999). "Regulation of G protein-coupled receptor kinases by caveolin". The Journal of Biological Chemistry 274 (13): 8858–64. doi:10.1074/jbc.274.13.8858. PMID 10085129. 
  • Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S (Sep 1999). "Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium". The Journal of Endocrinology 162 (3): 401–8. doi:10.1677/joe.0.1620401. PMID 10467231. 
  • Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (Jan 2000). "Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein". The Journal of Biological Chemistry 275 (1): 390–7. doi:10.1074/jbc.275.1.390. PMID 10617630. 
  • Pronin AN, Morris AJ, Surguchov A, Benovic JL (Aug 2000). "Synucleins are a novel class of substrates for G protein-coupled receptor kinases". The Journal of Biological Chemistry 275 (34): 26515–22. doi:10.1074/jbc.M003542200. PMID 10852916. 
  • Berrada K, Plesnicher CL, Luo X, Thibonnier M (Sep 2000). "Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation". The Journal of Biological Chemistry 275 (35): 27229–37. doi:10.1074/jbc.M002288200. PMID 10858434. 
  • Zhou H, Yan F, Tai HH (Sep 2001). "Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases". The Journal of Pharmacology and Experimental Therapeutics 298 (3): 1243–51. PMID 11504827. 
  • Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, Dikic I (Nov 2001). "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function". The Journal of Biological Chemistry 276 (44): 40431–40. doi:10.1074/jbc.M107024200. PMID 11517230. 
  • Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ (Jan 2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". The Journal of Biological Chemistry 277 (2): 1607–13. doi:10.1074/jbc.M107297200. PMID 11700307. 
  • Warabi K, Richardson MD, Barry WT, Yamaguchi K, Roush ED, Nishimura K, Kwatra MM (Jun 2002). "Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro". FEBS Letters 521 (1-3): 140–4. doi:10.1016/S0014-5793(02)02858-2. PMID 12067742.