ZAK

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MAP3K20
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAP3K20, AZK, MLK7, MLT, MLTK, MRK, mlklak, pk, ZAK, SFMMP, sterile alpha motif and leucine zipper containing kinase AZK, mitogen-activated protein kinase kinase kinase 20, MLTKalpha, MLTKbeta, CNM6
External IDsMGI: 2443258 HomoloGene: 32331 GeneCards: MAP3K20
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for MAP3K20
Genomic location for MAP3K20
Band2q31.1Start173,075,435 bp[1]
End173,268,010 bp[1]
RNA expression pattern
PBB GE ZAK 218833 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016653
NM_133646

NM_001164791
NM_023057
NM_178084

RefSeq (protein)

NP_057737
NP_598407

NP_001158263
NP_075544
NP_835185

Location (UCSC)Chr 2: 173.08 – 173.27 MbChr 2: 72.29 – 72.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.[5]

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]

Interactions[edit]

ZAK has been shown to interact with ZNF33A.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000091436 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004085 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK".
  6. ^ Yang, Jaw-Ji (Jan 2003). "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochem. Biophys. Res. Commun. United States. 301 (1): 71–7. doi:10.1016/S0006-291X(02)02980-7. ISSN 0006-291X. PMID 12535642.

Further reading[edit]