ZAK

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ZAK
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ZAK, AZK, MLK7, MLT, MLTK, MRK, mlklak, pk, SFMMP, sterile alpha motif and leucine zipper containing kinase AZK
External IDs MGI: 2443258 HomoloGene: 32331 GeneCards: ZAK
RNA expression pattern
PBB GE ZAK 218833 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016653
NM_133646

NM_001164791
NM_023057
NM_178084

RefSeq (protein)

NP_057737.2
NP_598407.1

NP_001158263.1
NP_075544.1
NP_835185.2

Location (UCSC) Chr 2: 173.08 – 173.27 Mb Chr 2: 72.29 – 72.44 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.[3]

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

Interactions[edit]

ZAK has been shown to interact with ZNF33A.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK". 
  4. ^ Yang, Jaw-Ji (Jan 2003). "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochem. Biophys. Res. Commun. United States. 301 (1): 71–7. doi:10.1016/S0006-291X(02)02980-7. ISSN 0006-291X. PMID 12535642. 

Further reading[edit]