AKT3

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
AKT3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAKT3, MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2, AKT serine/threonine kinase 3
External IDsOMIM: 611223 MGI: 1345147 HomoloGene: 55904 GeneCards: AKT3
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for AKT3
Genomic location for AKT3
Band1q43-q44Start243,488,233 bp[1]
End243,851,079 bp[1]
RNA expression pattern
PBB GE AKT3 219393 s at fs.png

PBB GE AKT3 212607 at fs.png

PBB GE AKT3 212609 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206729
NM_005465
NM_181690
NM_001370074

NM_011785

RefSeq (protein)

NP_001193658
NP_005456
NP_859029
NP_001357003

NP_035915

Location (UCSC)Chr 1: 243.49 – 243.85 MbChr 1: 177.02 – 177.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT3 gene.[5][6]

Function[edit]

The protein encoded by this gene is a member of the AKT subfamily of serine/threonine protein kinases. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.[7] Mice lacking Akt3 have a normal glucose metabolism (no diabetes), have approximately normal body weight, but have a 25% reduction in brain mass. Incidentally, Akt3 is highly expressed in the brain.

Interactions[edit]

AKT3 has been shown to interact with Protein kinase Mζ.[8]

References[edit]

  1. ^ a b c ENSG00000275199 GRCh38: Ensembl release 89: ENSG00000117020, ENSG00000275199 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019699 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Brodbeck D, Cron P, Hemmings BA (Apr 1999). "A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain". J Biol Chem. 274 (14): 9133–6. doi:10.1074/jbc.274.14.9133. PMID 10092583.
  6. ^ Nakatani K, Sakaue H, Thompson DA, Weigel RJ, Roth RA (Jun 1999). "Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site". Biochem Biophys Res Commun. 257 (3): 906–10. doi:10.1006/bbrc.1999.0559. PMID 10208883.
  7. ^ "Entrez Gene: AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)".
  8. ^ Hodgkinson CP, Sale EM, Sale GJ (2002). "Characterization of PDK2 activity against protein kinase B gamma". Biochemistry. 41 (32): 10351–9. doi:10.1021/bi026065r. PMID 12162751.

Further reading[edit]

External links[edit]