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Protein STK4 PDB 2jo8.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases STK4, KRS2, MST1, TIIAC, YSK3, serine/threonine kinase 4
External IDs MGI: 1929004 HomoloGene: 55965 GeneCards: STK4
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for STK4
Genomic location for STK4
Band 20q13.12 Start 44,966,474 bp[1]
End 45,079,959 bp[1]
RNA expression pattern
PBB GE STK4 205411 at fs.png

PBB GE STK4 211085 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 20: 44.97 – 45.08 Mb Chr 20: 164.07 – 164.16 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.[5][6][7]


The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.[8]


STK4 has been shown to interact with PRKRIR.[9]

STK4 has also been shown to prevent, through Yap1 coactivator modulation, haematological tumor cell apoptosis. Cottini F, Hideshima T, Xu C, Sattler M, Dori M, Agnelli L, ten Hacken E, Bertilaccio MT, Antonini E, Neri A, Ponzoni M, Marcatti M, Richardson PG, Carrasco R, Kimmelman AC, Wong KK, Caligaris-Cappio F, Blandino G, Kuehl WM, Anderson KC, Tonon G (2014). "Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers". Nat. Med. 20 (6): 599–606. PMC 4057660Freely accessible. PMID 24813251. doi:10.1038/nm.3562. 


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101109 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018209 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Taylor LK, Wang HC, Erikson RL (November 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10099–104. PMC 38343Freely accessible. PMID 8816758. doi:10.1073/pnas.93.19.10099. 
  6. ^ Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, Krebs EG (June 1998). "Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1". EMBO J. 17 (8): 2224–34. PMC 1170567Freely accessible. PMID 9545236. doi:10.1093/emboj/17.8.2224. 
  7. ^ Ura S, Masuyama N, Graves JD, Gotoh Y (August 2001). "Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10148–53. PMC 56930Freely accessible. PMID 11517310. doi:10.1073/pnas.181161698. 
  8. ^ "Entrez Gene: STK4 serine/threonine kinase 4". 
  9. ^ Lin Y, Khokhlatchev A, Figeys D, Avruch J (December 2002). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. 277 (50): 47991–8001. PMID 12384512. doi:10.1074/jbc.M202630200. 

Further reading[edit]