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Serine/threonine kinase 4
Protein STK4 PDB 2jo8.png
PDB rendering based on 2jo8.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols STK4 ; KRS2; MST1; TIIAC; YSK3
External IDs OMIM604965 MGI1929004 HomoloGene55965 ChEMBL: 4598 GeneCards: STK4 Gene
EC number
RNA expression pattern
PBB GE STK4 205411 at tn.png
PBB GE STK4 211085 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6789 58231
Ensembl ENSG00000101109 ENSMUSG00000018209
UniProt Q13043 Q9JI11
RefSeq (mRNA) NM_006282 NM_021420
RefSeq (protein) NP_006273 NP_067395
Location (UCSC) Chr 20:
44.97 – 45.08 Mb
Chr 2:
164.07 – 164.16 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.[1][2][3]


The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.[4]


STK4 has been shown to interact with PRKRIR.[5]

STK4 has also been shown to prevent, through Yap1 coactivator modulation, haematological tumor cell apoptosis. Cottini F, Hideshima T, Xu C, Sattler M, Dori M, Agnelli L, ten Hacken E, Bertilaccio MT, Antonini E, Neri A, Ponzoni M, Marcatti M, Richardson PG, Carrasco R, Kimmelman AC, Wong KK, Caligaris-Cappio F, Blandino G, Kuehl WM, Anderson KC, Tonon G (2014). "Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers". Nat. Med. 20 (6): 599–606. doi:10.1038/nm.3562. PMID 24813251. 


  1. ^ Taylor LK, Wang HC, Erikson RL (November 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10099–104. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758. 
  2. ^ Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, Krebs EG (June 1998). "Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1". EMBO J. 17 (8): 2224–34. doi:10.1093/emboj/17.8.2224. PMC 1170567. PMID 9545236. 
  3. ^ Ura S, Masuyama N, Graves JD, Gotoh Y (August 2001). "Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10148–53. doi:10.1073/pnas.181161698. PMC 56930. PMID 11517310. 
  4. ^ "Entrez Gene: STK4 serine/threonine kinase 4". 
  5. ^ Lin Y, Khokhlatchev A, Figeys D, Avruch J (December 2002). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. 277 (50): 47991–8001. doi:10.1074/jbc.M202630200. PMID 12384512. 

Further reading[edit]