RPS6KB2

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RPS6KB2
Identifiers
Aliases RPS6KB2, KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb, ribosomal protein S6 kinase B2
External IDs MGI: 1927343 HomoloGene: 68374 GeneCards: RPS6KB2
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for RPS6KB2
Genomic location for RPS6KB2
Band 11q13.2 Start 67,428,460 bp[1]
End 67,435,408 bp[1]
RNA expression pattern
PBB GE RPS6KB2 203777 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001007071
NM_003952

NM_021485

RefSeq (protein)

NP_003943

NP_067460.1

Location (UCSC) Chr 11: 67.43 – 67.44 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.[4][5][6]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two nonidentical kinase catalytic domains and phosphorilates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175634 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Saitoh M, ten Dijke P, Miyazono K, Ichijo H (Jan 1999). "Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases". Biochem Biophys Res Commun. 253 (2): 470–476. doi:10.1006/bbrc.1998.9784. PMID 9878560. 
  5. ^ Gout I, Minami T, Hara K, Tsujishita Y, Filonenko V, Waterfield MD, Yonezawa K (Dec 1998). "Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region". J Biol Chem. 273 (46): 30061–30064. doi:10.1074/jbc.273.46.30061. PMID 9804755. 
  6. ^ a b "Entrez Gene: RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2". 

Further reading[edit]