RPS6KB2

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Ribosomal protein S6 kinase, 70kDa, polypeptide 2
Identifiers
Symbols RPS6KB2 ; KLS; P70-beta; P70-beta-1; P70-beta-2; S6K-beta2; S6K2; SRK; STK14B; p70(S6K)-beta; p70S6Kb
External IDs OMIM608939 MGI1927343 HomoloGene68374 ChEMBL: 3111 GeneCards: RPS6KB2 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE RPS6KB2 203777 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6199 58988
Ensembl ENSG00000175634 ENSMUSG00000024830
UniProt Q9UBS0 Q9Z1M4
RefSeq (mRNA) NM_001007071 NM_021485
RefSeq (protein) NP_003943 NP_067460
Location (UCSC) Chr 11:
67.43 – 67.44 Mb
Chr 19:
4.16 – 4.16 Mb
PubMed search [1] [2]

Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.[1][2][3]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two nonidentical kinase catalytic domains and phosphorilates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.[3]

References[edit]

  1. ^ Saitoh M, ten Dijke P, Miyazono K, Ichijo H (Jan 1999). "Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases". Biochem Biophys Res Commun 253 (2): 470–476. doi:10.1006/bbrc.1998.9784. PMID 9878560. 
  2. ^ Gout I, Minami T, Hara K, Tsujishita Y, Filonenko V, Waterfield MD, Yonezawa K (Dec 1998). "Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region". J Biol Chem 273 (46): 30061–30064. doi:10.1074/jbc.273.46.30061. PMID 9804755. 
  3. ^ a b "Entrez Gene: RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2". 

Further reading[edit]