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Aliases TRIB2, C5FW, GS3955, TRB2, tribbles pseudokinase 2
External IDs MGI: 2145021 HomoloGene: 41445 GeneCards: TRIB2
RNA expression pattern
PBB GE TRIB2 202478 at fs.png

PBB GE TRIB2 202479 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 12.72 – 12.74 Mb Chr 12: 15.79 – 15.82 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Tribbles homolog 2 is an atypical protein kinase that is encoded in human by the TRIB2 gene.[3][4][5][6] TRIB2 is a pseudokinase member of the (pseudoenzyme) class of signaling/scaffold proteins, possessing little vestigial catalytic output in vitro.[7] It is known to signal to canonical MAPK pathways and to regulate the ubiquitination of substrates with important functions in the immune system. It has also been associated with various diseases, especially in vertebrate leukaemia models.[8] Like TRIB1 and TRIB3, TRIB2 has recently been considered as a potential allosteric drug target, [9][10] and is a putative regulator of cancer-associated signalling and survival through AKT pSer473 modulation [11]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wu M, Xu LG, Zhai Z, Shu HB (Jul 2003). "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription". J Biol Chem. 278 (29): 27072–9. PMID 12736262. doi:10.1074/jbc.M209814200. 
  4. ^ Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, Rodriguez CG, Maillard I, Tobias JW, Valk P, Carroll M, Aster JC, Delwel R, Pear WS (Nov 2006). "Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia". Cancer Cell. 10 (5): 401–11. PMC 2839500Freely accessible. PMID 17097562. doi:10.1016/j.ccr.2006.09.012. 
  5. ^ Hegedus Z, Czibula A, Kiss-Toth E (Aug 2006). "Tribbles: novel regulators of cell function; evolutionary aspects". Cell Mol Life Sci. 63 (14): 1632–41. PMID 16715410. doi:10.1007/s00018-006-6007-9. 
  6. ^ "Entrez Gene: TRIB2 tribbles homolog 2 (Drosophila)". 
  7. ^ Bailey FP, et al. (2015). "The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner.". Biochem Soc Transactions. 467 (1): 47–62. PMID 25583260. doi:10.1042/BJ20141441. 
  8. ^ Eyers PA, Keeshan K, Kannan N (2016). "Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease.". Trends in Cell Biology. In Press (9): S0962–8924(16)30178–7. PMID 27908682. doi:10.1016/j.tcb.2016.11.002. 
  9. ^ Foulkes DM, Byrne DP, Eyers PA (2015). "Tribbles pseudokinases: novel targets for chemical biology and drug discovery?". Biochem Soc Transactions. 43 (5): 1095–1103. PMID 26517930. doi:10.1042/BST20150109. 
  10. ^ Byrne DP, Foulkes DM, Eyers PA (2017). "Pseudokinases: update on their functions and evaluation as new drug targets.". Future Medicinal Chemistry. 9 (2): 245–265. PMID 28097887. doi:10.4155/fmc-2016-0207. 
  11. ^ Hill R, Madureira PA, Ferreira B, Baptista I, Machado S, Colaço L, Dos Santos M, Liu N, Dopazo A, Ugurel S, Adrienn A, Kiss-Toth E, Isbilen M, Gure AO, Link W (2017). "TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT". Nature Communications. 8 (5): 14687. PMID 28276427. doi:10.1038/ncomms14687. 

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