Tribbles homolog 2 is an atypical protein kinase that is encoded in human by the TRIB2gene. TRIB2 is a pseudokinase (pseudoenzyme), possessing little vestigial catalytic output. It is known to signal to canonical MAPK pathways and to regulate the ubiquitination of substrates with important functions in the immune system. It has also been associated with various diseases, especially in vertebrate leukaemia models. Like TRIB1 and TRIB3, TRIB2 has recently been considered as a potential allosteric drug target.
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