MAPK6

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MAPK6
Protein MAPK6 PDB 2i6l.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAPK6, ERK3, HsT17250, PRKM6, p97MAPK, mitogen-activated protein kinase 6
External IDs MGI: 1354946 HomoloGene: 55683 GeneCards: MAPK6
RNA expression pattern
PBB GE MAPK6 207121 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002748

NM_015806
NM_027418

RefSeq (protein)

NP_002739

NP_056621.4
NP_081694.1
NP_056621
NP_081694

Location (UCSC) Chr 15: 51.95 – 52.07 Mb Chr 9: 75.37 – 75.41 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene.[3][4]

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Meloche S, Beatty BG, Pellerin J (Dec 1996). "Primary structure, expression and chromosomal locus of a human homolog of rat ERK3". Oncogene. 13 (7): 1575–9. PMID 8875998. 
  4. ^ a b "Entrez Gene: MAPK6 mitogen-activated protein kinase 6". 

External links[edit]

Further reading[edit]