Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10gene.
This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.
^Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H (Jun 1999). "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues". Immunogenetics49 (5): 369–75. doi:10.1007/s002510050509. PMID10199912.
Kuramochi S, Moriguchi T, Kuida K, et al. (1997). "LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes.". J. Biol. Chem.272 (36): 22679–84. doi:10.1074/jbc.272.36.22679. PMID9278426.
Walter SA, Cutler RE, Martinez R, et al. (2003). "Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue.". J. Biol. Chem.278 (20): 18221–8. doi:10.1074/jbc.M212556200. PMID12639966.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Bignell G, Smith R, Hunter C, et al. (2006). "Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults.". Genes Chromosomes Cancer45 (1): 42–6. doi:10.1002/gcc.20265. PMID16175573.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol.24 (10): 1285–92. doi:10.1038/nbt1240. PMID16964243.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID17192257.