STK10

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STK10
PBB Protein STK10 image.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases STK10, LOK, PRO2729, serine/threonine kinase 10
External IDs MGI: 1099439 HomoloGene: 38122 GeneCards: 6793
RNA expression pattern
PBB GE STK10 203047 at tn.png

PBB GE STK10 40420 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005990

NM_009288

RefSeq (protein)

NP_005981.3

NP_033314.2

Location (UCSC) Chr 5: 172.04 – 172.19 Mb Chr 11: 32.53 – 32.62 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.[1][2]

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.[2]

References[edit]

  1. ^ Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H (Jun 1999). "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues". Immunogenetics 49 (5): 369–75. doi:10.1007/s002510050509. PMID 10199912. 
  2. ^ a b "Entrez Gene: STK10 serine/threonine kinase 10". 

Further reading[edit]