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Serine/threonine kinase 10
PBB Protein STK10 image.jpg
PDB rendering based on 2j7t.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols STK10 ; LOK; PRO2729
External IDs OMIM603919 MGI1099439 HomoloGene38122 IUPHAR: 2211 ChEMBL: 3981 GeneCards: STK10 Gene
EC number
RNA expression pattern
PBB GE STK10 40420 at tn.png
PBB GE STK10 203047 at tn.png
More reference expression data
Species Human Mouse
Entrez 6793 20868
Ensembl ENSG00000072786 ENSMUSG00000020272
UniProt O94804 O55098
RefSeq (mRNA) NM_005990 NM_009288
RefSeq (protein) NP_005981 NP_033314
Location (UCSC) Chr 5:
172.04 – 172.19 Mb
Chr 11:
32.53 – 32.62 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.[1][2]

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.[2]


  1. ^ Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H (Jun 1999). "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues". Immunogenetics 49 (5): 369–75. doi:10.1007/s002510050509. PMID 10199912. 
  2. ^ a b "Entrez Gene: STK10 serine/threonine kinase 10". 

Further reading[edit]