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For the airport in Alaska with ICAO code PASK, see Selawik Airport.
PAS domain containing serine/threonine kinase
Protein PASK PDB 1ll8.png
PDB rendering based on 1ll8.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PASK ; PASKIN; STK37
External IDs OMIM607505 MGI2155936 HomoloGene9038 IUPHAR: 2139 ChEMBL: 6054 GeneCards: PASK Gene
EC number
RNA expression pattern
PBB GE PASK 213534 s at tn.png
PBB GE PASK 216945 x at tn.png
More reference expression data
Species Human Mouse
Entrez 23178 269224
Ensembl ENSG00000115687 ENSMUSG00000026274
UniProt Q96RG2 Q8CEE6
RefSeq (mRNA) NM_001252119 NM_080850
RefSeq (protein) NP_001239048 NP_543126
Location (UCSC) Chr 2:
241.11 – 241.15 Mb
Chr 1:
93.31 – 93.34 Mb
PubMed search [1] [2]

PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.[1][2][3][4]

PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM][4]


  1. ^ Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM, Desbaillets I, Gassmann M, Wenger RH (Nov 2001). "Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors". Biochem Biophys Res Commun 288 (4): 757–64. doi:10.1006/bbrc.2001.5840. PMID 11688972. 
  2. ^ Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL (Aug 2001). "PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase". Proc Natl Acad Sci U S A 98 (16): 8991–6. doi:10.1073/pnas.161284798. PMC 55361. PMID 11459942. 
  3. ^ da Silva Xavier G, Rutter J, Rutter GA (Jun 2004). "Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose". Proc Natl Acad Sci U S A 101 (22): 8319–24. doi:10.1073/pnas.0307737101. PMC 420392. PMID 15148392. 
  4. ^ a b "Entrez Gene: PASK PAS domain containing serine/threonine kinase". 

Further reading[edit]