PASK

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PASK
Protein PASK PDB 1ll8.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PASK, PASKIN, STK37, PAS domain containing serine/threonine kinase
External IDs MGI: 2155936 HomoloGene: 9038 GeneCards: PASK
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PASK
Genomic location for PASK
Band 2q37.3 Start 241,106,099 bp[1]
End 241,150,264 bp[1]
RNA expression pattern
PBB GE PASK 213534 s at fs.png

PBB GE PASK 216945 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252119
NM_001252120
NM_001252122
NM_001252124
NM_015148

NM_080850

RefSeq (protein)

NP_001239048
NP_001239049
NP_001239051
NP_001239053
NP_055963

NP_543126

Location (UCSC) Chr 2: 241.11 – 241.15 Mb Chr 2: 93.31 – 93.34 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.[5][6][7][8]

PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115687 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026274 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM, Desbaillets I, Gassmann M, Wenger RH (Nov 2001). "Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors". Biochem Biophys Res Commun. 288 (4): 757–64. PMID 11688972. doi:10.1006/bbrc.2001.5840. 
  6. ^ Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL (Aug 2001). "PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase". Proc Natl Acad Sci U S A. 98 (16): 8991–6. PMC 55361Freely accessible. PMID 11459942. doi:10.1073/pnas.161284798. 
  7. ^ da Silva Xavier G, Rutter J, Rutter GA (Jun 2004). "Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose". Proc Natl Acad Sci U S A. 101 (22): 8319–24. PMC 420392Freely accessible. PMID 15148392. doi:10.1073/pnas.0307737101. 
  8. ^ a b "Entrez Gene: PASK PAS domain containing serine/threonine kinase". 

Further reading[edit]