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Maternal embryonic leucine zipper kinase
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MELK ; HPK38
External IDs OMIM607025 MGI106924 HomoloGene32111 ChEMBL: 4578 GeneCards: MELK Gene
EC number,
RNA expression pattern
PBB GE MELK 204825 at tn.png
More reference expression data
Species Human Mouse
Entrez 9833 17279
Ensembl ENSG00000165304 ENSMUSG00000035683
UniProt Q14680 Q61846
RefSeq (mRNA) NM_001256685 NM_010790
RefSeq (protein) NP_001243614 NP_034920
Location (UCSC) Chr 9:
36.57 – 36.68 Mb
Chr 4:
44.3 – 44.36 Mb
PubMed search [1] [2]

Maternal embryonic leucine zipper kinase is an enzyme that in humans is encoded by the MELK gene.[1][2][3]


MELK has been shown to interact with CDC25B.[4]


  1. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849. 
  2. ^ Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL (Aug 1997). "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Mol Reprod Dev 47 (2): 148–56. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115. 
  3. ^ "Entrez Gene: MELK maternal embryonic leucine zipper kinase". 
  4. ^ Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP (Oct 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. PMID 12400006. 

Further reading[edit]