MELK

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MELK
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MELK, HPK38, maternal embryonic leucine zipper kinase
External IDs MGI: 106924 HomoloGene: 32111 GeneCards: MELK
EC number 2.7.10.2
RNA expression pattern
PBB GE MELK 204825 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010790

RefSeq (protein)

NP_034920.2
NP_034920

Location (UCSC) Chr 9: 36.57 – 36.68 Mb Chr 4: 44.3 – 44.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Maternal embryonic leucine zipper kinase is an enzyme that in humans is encoded by the MELK gene.[3][4][5]

Interactions[edit]

MELK has been shown to interact with CDC25B.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849. 
  4. ^ Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL (Aug 1997). "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Mol Reprod Dev. 47 (2): 148–56. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115. 
  5. ^ "Entrez Gene: MELK maternal embryonic leucine zipper kinase". 
  6. ^ Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP (Oct 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. PMID 12400006. 

Further reading[edit]