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Protein PRKG1 PDB 1ZXA.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases PRKG1, 1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha, protein kinase, cGMP-dependent, type I
External IDs MGI: 108174 HomoloGene: 55964 GeneCards: PRKG1
Gene location (Human)
Chromosome 10 (human)
Chr. Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for PRKG1
Genomic location for PRKG1
Band 10q11.23-q21.1 Start 50,991,358 bp[1]
End 52,298,350 bp[1]
RNA expression pattern
PBB GE PRKG1 207119 at fs.png

PBB GE PRKG1 211380 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 10: 50.99 – 52.3 Mb Chr 10: 30.57 – 31.77 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.[5][6][7]


PRKG1 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185532 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052920 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Sep 1989). "Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat". FEBS Letters. 255 (2): 321–9. PMID 2792381. doi:10.1016/0014-5793(89)81114-7. 
  6. ^ Orstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T (April 1992). "Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell Genetics. 59 (4): 270–3. PMID 1544322. doi:10.1159/000133267. 
  7. ^ "Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I". 
  8. ^ Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB (Aug 2002). "cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I". The Journal of Biological Chemistry. 277 (35): 32003–14. PMID 12082086. doi:10.1074/jbc.M112332200. 
  9. ^ a b Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. PMID 10724174. doi:10.1038/35004606. 
  10. ^ Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (Jun 2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". The Journal of Biological Chemistry. 276 (26): 24153–9. PMID 11309393. doi:10.1074/jbc.M101530200. 
  11. ^ Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME, Tang M, Wang G (Dec 2003). "Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure". Nature Medicine. 9 (12): 1506–12. PMID 14608379. doi:10.1038/nm958. 
  12. ^ Yuasa K, Michibata H, Omori K, Yanaka N (Dec 1999). "A novel interaction of cGMP-dependent protein kinase I with troponin T". The Journal of Biological Chemistry. 274 (52): 37429–34. PMID 10601315. doi:10.1074/jbc.274.52.37429. 

Further reading[edit]