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Protein kinase, cGMP-dependent, type I
Protein PRKG1 PDB 1ZXA.png
Rendering based on PDB 1ZXA.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PRKG1 ; AAT8; PKG; PRKG1B; PRKGR1B; cGK; cGK 1; cGK1; cGKI; cGKI-BETA; cGKI-alpha
External IDs OMIM176894 MGI108174 HomoloGene55964 ChEMBL: 4273 GeneCards: PRKG1 Gene
EC number
RNA expression pattern
PBB GE PRKG1 211380 s at tn.png
PBB GE PRKG1 207119 at tn.png
More reference expression data
Species Human Mouse
Entrez 5592 19091
Ensembl ENSG00000185532 ENSMUSG00000052920
UniProt Q13976 P0C605
RefSeq (mRNA) NM_001098512 NM_001013833
RefSeq (protein) NP_001091982 NP_001013855
Location (UCSC) Chr 10:
50.99 – 52.3 Mb
Chr 19:
30.57 – 31.77 Mb
PubMed search [1] [2]

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.[1][2][3]


PRKG1 has been shown to interact with ITPR1,[4] RGS2,[5] TNNT1,[6] MRVI1[4][7] and GTF2I.[8]


  1. ^ Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (November 1989). "Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat". FEBS Lett 255 (2): 321–9. doi:10.1016/0014-5793(89)81114-7. PMID 2792381. 
  2. ^ Orstavik S, Sandberg M, Berube D, Natarajan V, Simard J, Walter U, Gagne R, Hansson V, Jahnsen T (April 1992). "Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenet Cell Genet 59 (4): 270–3. doi:10.1159/000133267. PMID 1544322. 
  3. ^ "Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I". 
  4. ^ a b Schlossmann, J; Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang G X, Allescher H D, Korth M, Wilm M, Hofmann F, Ruth P (March 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature (ENGLAND) 404 (6774): 197–201. doi:10.1038/35004606. ISSN 0028-0836. PMID 10724174. 
  5. ^ Tang, K Mary; Wang Guang-rong, Lu Ping, Karas Richard H, Aronovitz Mark, Heximer Scott P, Kaltenbronn Kevin M, Blumer Kendall J, Siderovski David P, Zhu Yan, Mendelsohn Michael E, Tang Mary, Wang Guang (December 2003). "Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure". Nat. Med. (United States) 9 (12): 1506–12. doi:10.1038/nm958. ISSN 1078-8956. PMID 14608379. 
  6. ^ Yuasa, K; Michibata H; Omori K; Yanaka N (December 1999). "A novel interaction of cGMP-dependent protein kinase I with troponin T". J. Biol. Chem. (UNITED STATES) 274 (52): 37429–34. doi:10.1074/jbc.274.52.37429. ISSN 0021-9258. PMID 10601315. 
  7. ^ Ammendola, A; Geiselhöringer A; Hofmann F; Schlossmann J (June 2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". J. Biol. Chem. (United States) 276 (26): 24153–9. doi:10.1074/jbc.M101530200. ISSN 0021-9258. PMID 11309393. 
  8. ^ Casteel, Darren E; Zhuang Shunhui; Gudi Tanima; Tang Julian; Vuica Milena; Desiderio Stephen; Pilz Renate B (August 2002). "cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I". J. Biol. Chem. (United States) 277 (35): 32003–14. doi:10.1074/jbc.M112332200. ISSN 0021-9258. PMID 12082086. 

Further reading[edit]