In enzymology, a tropomyosin kinase (EC 22.214.171.124) is an enzyme that catalyzes the chemical reaction
- ATP + tropomyosin ADP + O-phosphotropomyosin
Thus, the two substrates of this enzyme are ATP and tropomyosin, whereas its two products are ADP and O-phosphotropomyosin.
This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:tropomyosin O-phosphotransferase. Other names in common use include tropomyosin kinase (phosphorylating), and STK.
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- Montgomery K, Mak AS (1984). "In vitro phosphorylation of tropomyosin by a kinase from chicken embryo". J. Biol. Chem. 259 (9): 5555–60. PMID 6325440.
- Watson MH, Taneja AK, Hodges RS, Mak AS (1988). "Phosphorylation of alpha alpha- and beta beta-tropomyosin and synthetic peptide analogues". Biochemistry. 27 (12): 4506–12. PMID 3166994. doi:10.1021/bi00412a043.