PRKCI

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PRKCI
Protein PRKCI PDB 1vd2.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRKCI, DXS1179E, PKCI, nPKC-iota, protein kinase C iota
External IDs MGI: 99260 HomoloGene: 37667 GeneCards: 5584
RNA expression pattern
PBB GE PRKCI 209677 at tn.png

PBB GE PRKCI 209678 s at tn.png

PBB GE PRKCI 213518 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002740

NM_008857

RefSeq (protein)

NP_002731.4

NP_032883.2

Location (UCSC) Chr 3: 170.22 – 170.31 Mb Chr 3: 31 – 31.05 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.[1][2][3]

Function[edit]

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.[3]

Interactions[edit]

PRKCI has been shown to interact with:

References[edit]

  1. ^ Mazzarella R, Ciccodicola A, Esposito T, Arcucci A, Migliaccio C, Jones C, Schlessinger D, D'Urso M, D'Esposito M (Apr 1995). "Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3". Genomics 26 (3): 629–31. doi:10.1016/0888-7543(95)80190-W. PMID 7607695. 
  2. ^ De Donato M, Gallagher DS, Davis SK, Stelly DM, Taylor JF (April 2002). "The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3". Cytogenetics and Cell Genetics 95 (1-2): 79–81. doi:10.1159/000057021. PMID 11978974. 
  3. ^ a b "Entrez Gene: PRKCI protein kinase C, iota". 
  4. ^ Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A (Aug 2003). "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and Biophysical Research Communications 307 (3): 459–65. doi:10.1016/s0006-291x(03)01187-2. PMID 12893243. 
  5. ^ Lim YP, Low BC, Lim J, Wong ES, Guy GR (Jul 1999). "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling". The Journal of Biological Chemistry 274 (27): 19025–34. doi:10.1074/jbc.274.27.19025. PMID 10383403. 
  6. ^ Tisdale EJ (Feb 2002). "Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway". The Journal of Biological Chemistry 277 (5): 3334–41. doi:10.1074/jbc.M109744200. PMID 11724794. 
  7. ^ Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT (May 1998). "Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62". Molecular and Cellular Biology 18 (5): 3069–80. doi:10.1128/mcb.18.5.3069. PMC 110686. PMID 9566925. 
  8. ^ Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochemical and Biophysical Research Communications 299 (4): 641–6. doi:10.1016/s0006-291x(02)02698-0. PMID 12459187. 
  9. ^ Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR (Jul 2000). "A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1". The Journal of Biological Chemistry 275 (27): 20806–13. doi:10.1074/jbc.M000421200. PMID 10764742. 
  10. ^ Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J (Jan 1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Molecular and Cellular Biology 16 (1): 105–14. PMC 230983. PMID 8524286. 

Further reading[edit]