Phosphorylase kinase, alpha 1

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PHKA1
Identifiers
Aliases PHKA1, PHKA, Phosphorylase kinase, alpha 1, phosphorylase kinase regulatory subunit alpha 1
External IDs MGI: 97576 HomoloGene: 1981 GeneCards: PHKA1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001122670
NM_001172436
NM_002637

NM_008832
NM_173021

RefSeq (protein)

NP_001116142
NP_001165907
NP_002628

NP_032858.2
NP_032858
NP_766609

Location (UCSC) Chr X: 72.58 – 72.71 Mb Chr X: 102.51 – 102.64 Mb
PubMed search [1] [2]
Wikidata
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Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKA1 gene.[3]

The PHKA1 gene encodes the alpha subunit of muscle phosphorylase kinase (EC 2.7.1.38), a key regulatory enzyme of glycogen metabolism. Phosphorylase kinase consists of 4 copies of an alpha-beta-gamma-delta tetramer. The alpha, beta (PHKB; MIM 172490), and gamma (PHKG1; MIM 172470 and PHKG2; MIM 172471) subunits have several isoforms; the delta subunit is calmodulin (CALM1; MIM 114180). PHKA2 (MIM 306000) encodes the alpha subunit of liver-specific phosphorylase kinase and is also located on the X chromosome.[supplied by OMIM][3]

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