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Mitogen-activated protein kinase-activated protein kinase 5
External IDs OMIM606723 MGI1333110 HomoloGene69077 ChEMBL: 3094 GeneCards: MAPKAPK5 Gene
EC number
RNA expression pattern
PBB GE MAPKAPK5 212871 at tn.png
PBB GE MAPKAPK5 gnf1h00042 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8550 17165
Ensembl ENSG00000089022 ENSMUSG00000029454
UniProt Q8IW41 O54992
RefSeq (mRNA) NM_003668 NM_010765
RefSeq (protein) NP_003659 NP_034895
Location (UCSC) Chr 12:
111.84 – 111.9 Mb
Chr 5:
121.53 – 121.55 Mb
PubMed search [1] [2]

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene.[1][2] The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.[2]

A link between Alzheimer's disease and reduced levels of MAPKAPK5 has been proposed. But clinical trials are needed to confirm if this is the case.


  1. ^ New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J (Jul 1998). "PRAK, a novel protein kinase regulated by the p38 MAP kinase". EMBO J 17 (12): 3372–84. doi:10.1093/emboj/17.12.3372. PMC 1170675. PMID 9628874. 
  2. ^ a b "Entrez Gene: MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5". 

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