MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5gene. The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
A link between Alzheimer's disease and reduced levels of MAPKAPK5 has been proposed. But clinical trials are needed to confirm if this is the case.
de Carvalho MG, McCormack AL, Olson E, et al. (1996). "Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes.". J. Biol. Chem. 271 (12): 6987–97. PMID8636128. doi:10.1074/jbc.271.12.6987.
Börsch-Haubold AG, Bartoli F, Asselin J, et al. (1998). "Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells.". J. Biol. Chem. 273 (8): 4449–58. PMID9468497. doi:10.1074/jbc.273.8.4449.
Ni H, Wang XS, Diener K, Yao Z (1998). "MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase.". Biochem. Biophys. Res. Commun. 243 (2): 492–6. PMID9480836. doi:10.1006/bbrc.1998.8135.
Hefner Y, Borsch-Haubold AG, Murakami M, et al. (2001). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.". J. Biol. Chem. 275 (48): 37542–51. PMID10978317. doi:10.1074/jbc.M003395200.
Perfetti V, Casarini S, Palladini G, et al. (2002). "Analysis of V(lambda)-J(lambda) expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r (lambdaIII) as a new amyloid-associated germline gene segment.". Blood. 100 (3): 948–53. PMID12130507. doi:10.1182/blood-2002-01-0114.