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AliasesMAPKAPK5, MAPKAP-K5, MK-5, MK5, PRAK, mitogen-activated protein kinase-activated protein kinase 5, MAPK activated protein kinase 5
External IDsOMIM: 606723 MGI: 1333110 HomoloGene: 69077 GeneCards: MAPKAPK5
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for MAPKAPK5
Genomic location for MAPKAPK5
Band12q24.12-q24.13Start111,842,228 bp[1]
End111,902,222 bp[1]
RNA expression pattern
PBB GE MAPKAPK5 212871 at fs.png

PBB GE MAPKAPK5 gnf1h00042 s at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 12: 111.84 – 111.9 MbChr 5: 121.53 – 121.55 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene.[5][6] The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.[6]

A link between Alzheimer's disease and reduced levels of MAPKAPK5 has been proposed. Clinical trials may confirm if this is the case.


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089022 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029454 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J (Jul 1998). "PRAK, a novel protein kinase regulated by the p38 MAP kinase". EMBO J. 17 (12): 3372–84. doi:10.1093/emboj/17.12.3372. PMC 1170675. PMID 9628874.
  6. ^ a b "Entrez Gene: MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5".

Further reading[edit]