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Protein kinase, cAMP-dependent, catalytic, gamma
External IDs OMIM176893 HomoloGene55677 IUPHAR: 1478 ChEMBL: 2743 GeneCards: PRKACG Gene
EC number
RNA expression pattern
PBB GE PRKACG 207228 at tn.png
More reference expression data
Species Human Mouse
Entrez 5568 n/a
Ensembl ENSG00000165059 n/a
UniProt P22612 n/a
RefSeq (mRNA) NM_002732 n/a
RefSeq (protein) NP_002723 n/a
Location (UCSC) Chr 9:
69.01 – 69.01 Mb
PubMed search [1] n/a

cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene.[1][2][3]

Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.[3]


PRKACG has been shown to interact with Ryanodine receptor 2.[4]


  1. ^ Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T (June 1990). "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase". Mol Endocrinol 4 (3): 465–75. doi:10.1210/mend-4-3-465. PMID 2342480. 
  2. ^ Reinton N, Haugen TB, Orstavik S, Skalhegg BS, Hansson V, Jahnsen T, Tasken K (August 1998). "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon". Genomics 49 (2): 290–7. doi:10.1006/geno.1998.5240. PMID 9598317. 
  3. ^ a b "Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma". 
  4. ^ Marx, S O; Reiken S; Hisamatsu Y; Jayaraman T; Burkhoff D; Rosemblit N; Marks A R (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell (UNITED STATES) 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. ISSN 0092-8674. PMID 10830164. 

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