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Mitogen-activated protein kinase 13
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MAPK13 ; MAPK 13; MAPK-13; PRKM13; SAPK4; p38delta
External IDs OMIM602899 MGI1346864 HomoloGene48133 IUPHAR: 1502 GeneCards: MAPK13 Gene
EC number
Species Human Mouse
Entrez 5603 26415
Ensembl ENSG00000156711 ENSMUSG00000004864
UniProt O15264 Q9Z1B7
RefSeq (mRNA) NM_002754 NM_011950
RefSeq (protein) NP_002745 NP_036080
Location (UCSC) Chr 6:
36.1 – 36.11 Mb
Chr 17:
28.77 – 28.78 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene.[1]


The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.[1]


Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.