MAPK13

From Wikipedia, the free encyclopedia
Jump to: navigation, search
MAPK13
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAPK13, MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta, mitogen-activated protein kinase 13
External IDs MGI: 1346864 HomoloGene: 48133 GeneCards: 5603
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002754

NM_011950

RefSeq (protein)

NP_002745.1

NP_036080.2

Location (UCSC) Chr 6: 36.13 – 36.14 Mb Chr 17: 28.77 – 28.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene.[3]

Function[edit]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.[3]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.