PRKD2

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PRKD2
Protein PRKD2 PDB 2coa.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRKD2, PKD2, nPKC-D2, HSPC187, protein kinase D2
External IDs MGI: 2141917 HomoloGene: 9516 GeneCards: PRKD2
RNA expression pattern
PBB GE PRKD2 209282 at fs.png

PBB GE PRKD2 38269 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001079880
NM_001079881
NM_001079882
NM_016457

NM_001252458
NM_178900

RefSeq (protein)

NP_001073349
NP_001073350
NP_001073351
NP_057541

NP_001239387.1
NP_849231.1
NP_001239387
NP_849231

Location (UCSC) Chr 19: 46.67 – 46.72 Mb Chr 7: 16.84 – 16.87 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase D2 or PKD2 is an enzyme that in humans is encoded by the PRKD2 gene.[3][4][5]

Function[edit]

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases, a subfamily of protein kinase c. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934Freely accessible. PMID 11042152. 
  4. ^ Sturany S, Van Lint J, Muller F, Wilda M, Hameister H, Hocker M, Brey A, Gern U, Vandenheede J, Gress T, Adler G, Seufferlein T (May 2001). "Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases". J Biol Chem. 276 (5): 3310–8. doi:10.1074/jbc.M008719200. PMID 11062248. 
  5. ^ a b "Entrez Gene: PRKD2 protein kinase D2". 

Further reading[edit]