MAP kinase kinase kinase
| Mitogen-activated protein kinase kinase kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.11.25 | ||||||||
| CAS no. | 146702-84-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
MAP kinase kinase kinase (or MAP3K or MEKK) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase also known as Raf. In humans, there at least 19 genes encode MAP kinase kinase kinases:
- MAP3K1 (aka MEKK1)
- MAP3K2
- MAP3K3 (aka MEKK3)
- MAP3K4
- MAP3K5 (aka ASK1)
- MAP3K6 (aka ASK2)
- MAP3K7 (aka MEKK7) (aka TAK1)
- MAP3K8 (aka TPL2 or Tpl2)
- MAP3K9
- MAP3K10
- MAP3K11 (aka MEKK11) (aka MLK3)
- MAP3K12 (aka MUK)
- MAP3K13 (aka LZK)
- MAP3K14
- MAP3K15
- MAP3K16 (aka TAO1 or TAOK1)
- MAP3K17 (aka TAO2 or TAOK2)
- RAF1
- BRAF
- ARAF
- ZAK (aka MLTK)
Perhaps the best characterized MAP3K are the members of the oncogenic RAF family (RAF1, BRAF, ARAF), which are effectors of mitogenic ras signaling and which activate the ERK1/2 (MAPK3/MAPK1) pathway, through activation of MEK1(MAP2K1) and MEK2(MAP2K2).
MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4).[1]
MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway.[2]
MAP3K7(TAK1) participates in regulation of transcription by transforming growth factor-beta (TGF-beta).[3]
Additional images
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MAPK pathway. Many of the MAP3K's here are labelled by their alternative names.
See also
References
- ^ Yan M, Dai T, Deak JC, Kyriakis JM, Zon LI, Woodgett JR, Templeton DJ (1994). "Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1". Nature. 372 (6508): 798–800. doi:10.1038/372798a0. PMID 7997270.
- ^
Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U (January 1997). "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative". The Journal of Biological Chemistry. 272 (5): 2668–74. doi:10.1074/jbc.272.5.2668. PMID 9006902.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K (December 1995). "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction". Science. 270 (5244): 2008–11. doi:10.1126/science.270.5244.2008. PMID 8533096.
External links
- MAP+Kinase+Kinase+Kinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- EC 2.7.11.25
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