MKNK1

MKNK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HW6, 2Y9Q
Identifiers
Aliases	MKNK1, MNK1, MAP kinase interacting serine/threonine kinase 1, MAPK interacting serine/threonine kinase 1
External IDs	OMIM: 606724 MGI: 894316 HomoloGene: 37838 GeneCards: MKNK1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	46,616,843 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	115,736,447 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; spleen; ; blood; ; gastric mucosa; ; secondary oocyte; ; right coronary artery; ; upper lobe of left lung; ; monocyte; ; tibial nerve; ; ascending aorta;
	Top expressed in
	secondary oocyte; ; thymus; ; lip; ; pancreas; ; spleen; ; vastus lateralis muscle; ; calvaria; ; islet of Langerhans; ; parotid gland; ; lymph node;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; kinase activity; protein binding; calmodulin-dependent protein kinase activity; ATP binding; protein serine/threonine kinase activity; metal ion binding;
Cellular component	cytoplasm; cytosol; nucleoplasm; nucleus;
Biological process	intracellular signal transduction; phosphorylation; protein phosphorylation; protein autophosphorylation; regulation of translation; peptidyl-serine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	8569
	17346
	ENSG00000079277
	ENSMUSG00000028708
	Q9BUB5
	O08605
NM_001135553; NM_003684; NM_198973; NM_001377337; NM_001377338;
	NM_001377341; NM_001377342; NM_001377343; NM_001377373; NM_001377374; NM_001377375
	NM_001285487; NM_001285488; NM_021461; NM_001355174; NM_001369238
NP_001129025; NP_003675; NP_945324; NP_001364266; NP_001364267;
	NP_001364270; NP_001364271; NP_001364272; NP_001364302; NP_001364303; NP_001364304
	NP_001272416; NP_001272417; NP_067436; NP_001342103; NP_001356167
	Wikidata
View/Edit Human	View/Edit Mouse

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.^[5]^[6]

Template:PBB Summary

Interactions

MKNK1 has been shown to interact with MAPK1^[7] and Eukaryotic translation initiation factor 4 gamma.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000079277 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028708 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fukunaga R, Hunter T (Jun 1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J. 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMC 1169795. PMID 9155018.
^ "Entrez Gene: MKNK1 MAP kinase interacting serine/threonine kinase 1".
^ Waskiewicz, A J; Flynn A; Proud C G; Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. 16 (8). ENGLAND: 1909–20. doi:10.1093/emboj/16.8.1909. ISSN 0261-4189. PMC 1169794. PMID 9155017. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Pyronnet, S; Imataka H; Gingras A C; Fukunaga R; Hunter T; Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. 18 (1). ENGLAND: 270–9. doi:10.1093/emboj/18.1.270. ISSN 0261-4189. PMC 1171121. PMID 9878069. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Interactions

References

Further reading