RAF kinase

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The mitogen-activated protein kinase (MAPK) pathway.[1][2][3][4][5][6][7][8][9][10] RAF-1 is between RAS and MEK just above the centre of the diagram.

RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes.[11] The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for Rapidly Accelerated Fibrosarcoma.[12]

RAF kinases participate in the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade.[11] Activation of RAF kinases requires interaction with RAS-GTPases.

The three RAF kinase family members are:


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  11. ^ a b Roskoski R (August 2010). "RAF protein-serine/threonine kinases: structure and regulation" (PDF). Biochem. Biophys. Res. Commun. 399 (3): 313–7. doi:10.1016/j.bbrc.2010.07.092. PMID 20674547.
  12. ^ Zebisch A, Troppmair J (June 2006). "Back to the roots: the remarkable RAF oncogene story". Cell. Mol. Life Sci. 63 (11): 1314–30. doi:10.1007/s00018-006-6005-y. PMID 16649144.