Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the PCTK1gene.[5][6]
Function
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escape X inactivation. Two transcript variants encoding the same protein have been found for this gene.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene. 7 (11): 2249–58. PMID1437147.
Knight JC, Renwick PJ, Downing JR, Okuda T (1995). "Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3". Cytogenet. Cell Genet. 71 (2): 155–7. doi:10.1159/000134097. PMID7656587.
Okuda T, Valentine VA, Shapiro DN, Downing JR (1994). "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes". Genomics. 21 (1): 217–21. doi:10.1006/geno.1994.1245. PMID8088790.
Sladeczek F, Camonis JH, Burnol AF, Le Bouffant F (1997). "The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins". Mol. Gen. Genet. 254 (5): 571–7. doi:10.1007/s004380050453. PMID9197417. S2CID22809140.
Esposito T, Gianfrancesco F, Ciccodicola A, D'Esposito M, Nagaraja R, Mazzarella R, D'Urso M, Forabosco A (1997). "Escape from X inactivation of two new genes associated with DXS6974E and DXS7020E". Genomics. 43 (2): 183–90. doi:10.1006/geno.1997.4797. PMID9244435.
Besset V, Rhee K, Wolgemuth DJ (1999). "The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation". Cell Growth Differ. 10 (3): 173–81. PMID10099831.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID16189514. S2CID4427026.