MAPK13

MAPK13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3COI, 4EYJ, 4EYM, 4MYG, 4YNO, 5EKO, 5EKN
Identifiers
Aliases	MAPK13, MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta, mitogen-activated protein kinase 13
External IDs	OMIM: 602899; MGI: 1346864; HomoloGene: 48133; GeneCards: MAPK13; OMA:MAPK13 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.31 Start 36,127,809 bp End 36,144,524 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A3.3 Start 28,988,271 bp End 28,999,207 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums mucosa of transverse colon right adrenal gland right adrenal cortex gingival epithelium left adrenal gland mucosa of ileum human penis left adrenal cortex parotid gland Top expressed in granulocyte lip crypt of lieberkuhn of small intestine epithelium of stomach duodenum large intestine ileum colon intestinal villus jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity MAP kinase activity kinase activity protein serine/threonine kinase activity protein binding ATP binding Cellular component cytosol nucleus cytoplasm Biological process positive regulation of inflammatory response regulation of transcription, DNA-templated phosphorylation transcription, DNA-templated response to osmotic stress protein phosphorylation peptidyl-serine phosphorylation positive regulation of interleukin-6 production cell cycle regulation of gene expression cellular response to UV stress-activated MAPK cascade cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to sorbitol cellular response to anisomycin cellular response to sodium arsenite MAPK cascade intracellular signal transduction cellular response to organic substance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5603 26415 Ensembl ENSG00000156711 ENSMUSG00000004864 UniProt O15264 Q9Z1B7 RefSeq (mRNA) NM_002754 NM_011950 RefSeq (protein) NP_002745 NP_036080 Location (UCSC) Chr 6: 36.13 – 36.14 Mb Chr 17: 28.99 – 29 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene.

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.

Further reading

• Efimova T, Broome AM, Eckert RL (2004). "Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex". Mol. Cell. Biol. 24 (18): 8167–83. doi:10.1128/MCB.24.18.8167-8183.2004. PMC 515052. PMID 15340077.
• Joneson T, Bar-Sagi D (1997). "Ras effectors and their role in mitogenesis and oncogenesis". J. Mol. Med. 75 (8): 587–93. doi:10.1007/s001090050143. PMID 9297626.
• Efimova T (2010). "p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis". Cell Cycle. 9 (3): 498–05. doi:10.4161/cc.9.3.10541. PMID 20090411.
• Gutierrez-Sanmartin D, Varela-Ledo E, Aguilera A, et al. (2008). "Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I." J. Gen. Virol. 89 (Pt 7): 1661–71. doi:10.1099/vir.0.82971-0. PMID 18559936.
• Zhang J, Harrison JS, Studzinski GP (2011). "Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D₃". Exp. Cell Res. 317 (1): 117–30. doi:10.1016/j.yexcr.2010.08.010. PMC 2998239. PMID 20804750.
• Segat L, Brandão LA, Guimarães RL, et al. (2010). "Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment". Vaccine. 28 (10): 2201–6. doi:10.1016/j.vaccine.2009.12.056. PMID 20056178.
• Zhou X, Ferraris JD, Dmitrieva NI, et al. (2008). "MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta". Proc. Natl. Acad. Sci. U.S.A. 105 (14): 5620–5. doi:10.1073/pnas.0801453105. PMC 2291081. PMID 18367666.
• Coulthard LR, Taylor JC, Eyre S, et al. (2011). "Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients". Ann. Rheum. Dis. 70 (1): 98–103. doi:10.1136/ard.2010.133249. PMID 20805296.
• Efimova T, Broome AM, Eckert RL (2003). "A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation". J. Biol. Chem. 278 (36): 34277–85. doi:10.1074/jbc.M302759200. PMID 12810719.
• Kim SJ, Zhang Z, Hitomi E, et al. (2006). "Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL". Hum. Mol. Genet. 15 (11): 1826–34. doi:10.1093/hmg/ddl105. PMID 16644870.
• Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ozawa S, Ito S, Kato Y, et al. (2010). "Human p38 delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14". Biochem. Biophys. Res. Commun. 396 (4): 1060–4. doi:10.1016/j.bbrc.2010.05.072. PMID 20478268.
• Kitatani K, Sheldon K, Anelli V, et al. (2009). "Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid". J. Biol. Chem. 284 (19): 12979–88. doi:10.1074/jbc.M809500200. PMC 2676030. PMID 19279008.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Tan FL, Ooi A, Huang D, et al. (2010). "p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion". Int. J. Cancer. 126 (10): 2353–61. doi:10.1002/ijc.24944. PMID 19816939.
• Sofroniew MV, Howe CL, Mobley WC (2001). "Nerve growth factor signaling, neuroprotection, and neural repair". Annu. Rev. Neurosci. 24: 1217–81. doi:10.1146/annurev.neuro.24.1.1217. PMID 11520933.
• Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Sumara G, Formentini I, Collins S, et al. (2009). "Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis". Cell. 136 (2): 235–48. doi:10.1016/j.cell.2008.11.018. PMC 2638021. PMID 19135240.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.