DAPK2

DAPK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WMK, 1WRZ, 1Z9X, 1ZUZ, 1ZWS, 2A27, 2A2A, 2CKE
Identifiers
Aliases	DAPK2, DRP-1, DRP1, death-associated protein kinase 2, death associated protein kinase 2
External IDs	OMIM: 616567; MGI: 1341297; HomoloGene: 74940; GeneCards: DAPK2; OMA:DAPK2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,072,033 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	66,272,242 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right auricle; ; right lung; ; gastrocnemius muscle; ; muscle of thigh; ; upper lobe of left lung; ; left ventricle; ; blood; ; sural nerve;
	Top expressed in
	muscle of thigh; ; membranous bone; ; body of femur; ; lumbar spinal ganglion; ; Dermatocranium; ; maxilla; ; lip; ; right lung; ; right lung lobe; ; tibiofemoral joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; calmodulin binding; kinase activity; protein serine/threonine kinase activity; protein binding; identical protein binding; ATP binding;
Cellular component	cytoplasm; autophagosome lumen; cytoplasmic vesicle; Golgi apparatus; intracellular membrane-bounded organelle; nucleus;
Biological process	regulation of apoptotic process; intracellular signal transduction; regulation of intrinsic apoptotic signaling pathway; phosphorylation; protein phosphorylation; positive regulation of eosinophil chemotaxis; regulation of autophagy; anoikis; positive regulation of neutrophil chemotaxis; protein autophosphorylation; neutrophil migration; apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	23604
	13143
	ENSG00000035664
	ENSMUSG00000032380
	Q9UIK4
	Q8VDF3
NM_014326; NM_001363730; NM_001384997; NM_001384998; NM_001384999;
	NM_001385000
	NM_010019
	NP_055141; NP_001350659
	NP_034149; NP_001391612
	Wikidata
View/Edit Human	View/Edit Mouse

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000035664 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032380 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S (Jun 1999). "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity". Oncogene. 18 (23): 3471–80. doi:10.1038/sj.onc.1202701. PMID 10376525.
^ "Entrez Gene: DAPK2 death-associated protein kinase 2".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading