GRK4

GRK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YHJ
Identifiers
Aliases	GRK4, GPRK2L, GPRK4, GRK4a, IT11, G protein-coupled receptor kinase 4
External IDs	OMIM: 137026 MGI: 95801 HomoloGene: 23158 GeneCards: GRK4
Gene location (Human)
Chr.	Chromosome 4 (human)
End	3,040,760 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	34,755,305 bp
RNA expression pattern
	Top expressed in
	sperm; ; cerebellar hemisphere; ; anterior pituitary; ; cingulate gyrus; ; Brodmann area 9; ; body of pancreas; ; ganglionic eminence; ; amygdala; ; tibial nerve; ; nucleus accumbens;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; retinal pigment epithelium; ; morula; ; thymus; ; superior frontal gyrus; ; proximal tubule; ; lip; ; saccule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; G protein-coupled receptor kinase activity; kinase activity; protein serine/threonine kinase activity; ATP binding; rhodopsin kinase activity;
Cellular component	cytoplasm; cytosol; neuronal cell body; dendrite; cell cortex; photoreceptor disc membrane;
Biological process	G protein-coupled receptor internalization; regulation of G protein-coupled receptor signaling pathway; phosphorylation; regulation of rhodopsin mediated signaling pathway; receptor internalization; protein phosphorylation; desensitization of G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2868
	14772
	ENSG00000125388
	ENSMUSG00000052783
	P32298
	O70291
	NM_001004056; NM_001004057; NM_005307; NM_182982; NM_001350173
	NM_001080743; NM_019497
	NP_001004056; NP_001004057; NP_005298; NP_892027; NP_001337102
	NP_001074212; NP_062370
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled receptor kinase 4 is an enzyme that in humans is encoded by the GRK4 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125388 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052783 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ambrose C, James M, Barnes G, Lin C, Bates G, Altherr M, Duyao M, Groot N, Church D, Wasmuth JJ, et al. (Jun 1993). "A novel G protein-coupled receptor kinase gene cloned from 4p16.3". Hum Mol Genet. 1 (9): 697–703. doi:10.1093/hmg/1.9.697. PMID 1338872.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading