GRK6

GRK6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ACX, 3NYN, 3NYO
Identifiers
Aliases	GRK6, GPRK6, G protein-coupled receptor kinase 6
External IDs	OMIM: 600869; MGI: 1347078; HomoloGene: 37570; GeneCards: GRK6; OMA:GRK6 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,442,901 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,608,740 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; monocyte; ; bone marrow cells; ; lymph node; ; spleen; ; appendix; ; beta cell; ; pancreatic ductal cell; ; male germ cell;
	Top expressed in
	mesenteric lymph nodes; ; Paneth cell; ; internal carotid artery; ; condyle; ; fossa; ; external carotid artery; ; granulocyte; ; Rostral migratory stream; ; blood; ; spleen;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; G protein-coupled receptor kinase activity; kinase activity; beta-adrenergic receptor kinase activity;
Cellular component	membrane; plasma membrane;
Biological process	protein phosphorylation; Wnt signaling pathway; phosphorylation; regulation of G protein-coupled receptor signaling pathway; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2870
	26385
	ENSG00000198055
	ENSMUSG00000074886
	P43250
	O70293
	NM_001004105; NM_001004106; NM_002082; NM_001364164
NM_001038018; NM_001112711; NM_001286063; NM_001286064; NM_001286065;
	NM_001286066; NM_011938; NM_001377076; NM_001377077
	NP_001004105; NP_001004106; NP_002073; NP_001351093
NP_001033107; NP_001106182; NP_001272992; NP_001272993; NP_001272994;
	NP_001272995; NP_036068; NP_001364005; NP_001364006
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled receptor kinase 6 is an enzyme that in humans is encoded by the GRK6 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198055 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074886 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Haribabu B, Snyderman R (Nov 1993). "Identification of additional members of human G-protein-coupled receptor kinase multigene family". Proc Natl Acad Sci U S A. 90 (20): 9398–402. doi:10.1073/pnas.90.20.9398. PMC 47575. PMID 8415712.
^ "Entrez Gene: GRK6 G protein-coupled receptor kinase 6".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading