LATS2

LATS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZRI
Identifiers
Aliases	LATS2, KPM, large tumor suppressor kinase 2
External IDs	OMIM: 604861; MGI: 1354386; HomoloGene: 56678; GeneCards: LATS2; OMA:LATS2 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	21,061,586 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	57,995,845 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; myocardium of left ventricle; ; visceral pleura; ; parietal pleura; ; tibialis anterior muscle; ; tibia; ; germinal epithelium; ; cardiac muscle tissue of right atrium; ; lower lobe of lung; ; amniotic fluid;
	Top expressed in
	ascending aorta; ; aortic valve; ; external carotid artery; ; sciatic nerve; ; cardiac muscle tissue of left ventricle; ; internal carotid artery; ; spermatid; ; left lung lobe; ; plantaris muscle; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; metal ion binding; kinase activity; protein binding; ATP binding; protein serine/threonine kinase activity;
Cellular component	spindle pole; microtubule organizing center; cytoskeleton; nucleus; cytoplasm; cytosol;
Biological process	intracellular signal transduction; phosphorylation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; cell division; protein phosphorylation; peptidyl-serine phosphorylation; hormone-mediated signaling pathway; positive regulation of apoptotic process; cell cycle; G1/S transition of mitotic cell cycle; hippo signaling; regulation of organ growth; negative regulation of canonical Wnt signaling pathway; inner cell mass cell fate commitment; inner cell mass cellular morphogenesis; keratinocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	26524
	50523
	ENSG00000150457
	ENSMUSG00000021959
	Q9NRM7
	Q7TSJ6
	NM_014572
	NM_015771; NM_153382
	NP_055387
	NP_056586; NP_700431
	Wikidata
View/Edit Human	View/Edit Mouse

Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150457 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021959 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics. 63 (2): 263–70. doi:10.1006/geno.1999.6065. PMID 10673337.
^ "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading