MAP2K3

MAP2K3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LEZ
Identifiers
Aliases	MAP2K3, MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2, mitogen-activated protein kinase kinase 3
External IDs	OMIM: 602315 MGI: 1346868 HomoloGene: 56430 GeneCards: MAP2K3
Gene location (Human)
Chr.	Chromosome 17 (human)
End	21,315,232 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	60,843,637 bp
RNA expression pattern
	Top expressed in
	vena cava; ; blood; ; body of tongue; ; saphenous vein; ; pylorus; ; superior surface of tongue; ; cardia; ; monocyte; ; pancreatic ductal cell; ; mucosa of urinary bladder;
	Top expressed in
	temporal muscle; ; sternocleidomastoid muscle; ; ankle; ; digastric muscle; ; triceps brachii muscle; ; lip; ; esophagus; ; vastus lateralis muscle; ; knee joint; ; skeletal muscle tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; protein tyrosine kinase activity; protein kinase activity; protein binding; kinase activity; nucleotide binding; transferase activity; MAP kinase kinase activity; protein kinase binding; protein serine/threonine kinase activity;
Cellular component	nucleoplasm; cytosol; membrane; cytoplasm;
Biological process	MAPK cascade; protein phosphorylation; positive regulation of transcription, DNA-templated; peptidyl-tyrosine phosphorylation; phosphorylation; signal transduction; positive regulation of protein kinase activity; inflammatory response; cardiac muscle contraction; regulation of mitotic cell cycle; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of apoptotic process; cellular response to vascular endothelial growth factor stimulus; p38MAPK cascade; positive regulation of blood vessel endothelial cell migration;
	Sources:Amigo / QuickGO
Orthologs
	5606
	26397
	ENSG00000034152
	ENSMUSG00000018932
	P46734
	O09110
	NM_002756; NM_145109; NM_145110; NM_001316332
	NM_008928
	NP_001303261; NP_002747; NP_659731
	NP_032954
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.^[5]

Template:PBB Summary

Interactions

MAP2K3 has been shown to interact with TAOK2^[6] and PLCB2.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000034152 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018932 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA (Mar 1998). "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5". Cytogenet Cell Genet. 78 (3–4): 301–3. doi:10.1159/000134677. PMID 9465908.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Chen, Z; Cobb M H (May 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". J. Biol. Chem. 276 (19). United States: 16070–5. doi:10.1074/jbc.M100681200. ISSN 0021-9258. PMID 11279118. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
^ Barr, Alastair J; Marjoram Robin; Xu Jing; Snyderman Ralph (Apr 2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3". Biochem. Biophys. Res. Commun. 293 (1). United States: 647–52. doi:10.1016/S0006-291X(02)00259-0. ISSN 0006-291X. PMID 12054652. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Interactions

References

Further reading