MAP kinase kinase kinase
|Mitogen-activated protein kinase kinase kinase|
|PDB structures||RCSB PDB PDBe PDBsum|
In humans, there are at least 19 genes:
- MAP3K1 (aka MEKK1)
- MAP3K3 (aka MEKK3)
- MAP3K5 (aka ASK1)
- MAP3K6 (aka ASK2)
- MAP3K7 (aka MEKK7) (aka TAK1)
- MAP3K8 (aka TPL2 or Tpl2)
- MAP3K11 (aka MEKK11) (aka MLK3)
- MAP3K12 (aka MUK)
- MAP3K13 (aka LZK)
- MAP3K16 (aka TAO1 or TAOK1)
- MAP3K17 (aka TAO2 or TAOK2)
- ZAK (aka MLTK)
Perhaps the best characterized MAP3K are the members of the oncogenic RAF family (RAF1, BRAF, ARAF), which are effectors of mitogenic ras signaling and which activate the ERK1/2 (MAPK3/MAPK1) pathway, through activation of MEK1(MAP2K1) and MEK2(MAP2K2).
MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway.
- Yan M, et al. (1994). "Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1". Nature. 372 (6508): 798–800. doi:10.1038/372798a0. PMID 7997270.
- Ellinger-Ziegelbauer H, et al. (1997). "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative". J Biol Chem. 272 (5): 2668–2674. doi:10.1074/jbc.272.5.2668. PMID 9006902.
- Yamaguchi K, et al. (1995). "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction". Science. 270 (5244): 2008–2011. doi:10.1126/science.270.5244.2008. PMID 8533096.
- MAP Kinase Kinase Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 126.96.36.199
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