PASK

PASK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LL8, 3DLS
Identifiers
Aliases	PASK, PASKIN, STK37, PAS domain containing serine/threonine kinase
External IDs	OMIM: 607505; MGI: 2155936; HomoloGene: 9038; GeneCards: PASK; OMA:PASK - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	241,150,264 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,271,204 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; oocyte; ; right testis; ; left testis; ; secondary oocyte; ; lymph node; ; appendix; ; caudate nucleus; ; putamen; ; nucleus accumbens;
	Top expressed in
	spermatocyte; ; spermatid; ; otic vesicle; ; otic placode; ; saccule; ; seminiferous tubule; ; epiblast; ; ventricular zone; ; tail of embryo; ; gastrula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; protein kinase activity; protein binding; ATP binding; phosphatidylinositol binding; lipid binding; protein serine/threonine kinase activity;
Cellular component	nucleus; cytosol; cytoplasm;
Biological process	regulation of respiratory gaseous exchange; protein autophosphorylation; negative regulation of glycogen biosynthetic process; positive regulation of translation; regulation of glucagon secretion; phosphorylation; protein phosphorylation; energy homeostasis; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23178
	269224
	ENSG00000115687
	ENSMUSG00000026274
	Q96RG2
	Q8CEE6
	NM_001252119; NM_001252120; NM_001252122; NM_001252124; NM_015148
	NM_080850
	NP_001239048; NP_001239049; NP_001239051; NP_001239053; NP_055963
	NP_543126
	Wikidata
View/Edit Human	View/Edit Mouse

PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.^[5]^[6]^[7]^[8]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115687 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026274 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM, Desbaillets I, Gassmann M, Wenger RH (Nov 2001). "Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors". Biochem Biophys Res Commun. 288 (4): 757–64. doi:10.1006/bbrc.2001.5840. PMID 11688972.
^ Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL (Aug 2001). "PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase". Proc Natl Acad Sci U S A. 98 (16): 8991–6. doi:10.1073/pnas.161284798. PMC 55361. PMID 11459942.
^ da Silva Xavier G, Rutter J, Rutter GA (Jun 2004). "Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose". Proc Natl Acad Sci U S A. 101 (22): 8319–24. doi:10.1073/pnas.0307737101. PMC 420392. PMID 15148392.
^ "Entrez Gene: PASK PAS domain containing serine/threonine kinase".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading