Phosphorylase kinase, alpha 1

PHKA1
Identifiers
Aliases	PHKA1, PHKA, Phosphorylase kinase, alpha 1, phosphorylase kinase regulatory subunit alpha 1
External IDs	OMIM: 311870; MGI: 97576; HomoloGene: 1981; GeneCards: PHKA1; OMA:PHKA1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	72,714,319 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	101,687,852 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; vastus lateralis muscle; ; Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; deltoid muscle; ; tibialis anterior muscle; ; triceps brachii muscle; ; right adrenal cortex;
	Top expressed in
	triceps brachii muscle; ; medial head of gastrocnemius muscle; ; vastus lateralis muscle; ; muscle of thigh; ; sternocleidomastoid muscle; ; temporal muscle; ; tibialis anterior muscle; ; digastric muscle; ; extensor digitorum longus muscle; ; masseter muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	catalytic activity; calmodulin binding; phosphorylase kinase activity;
Cellular component	cytosol; plasma membrane; membrane; phosphorylase kinase complex;
Biological process	glycogen metabolic process; generation of precursor metabolites and energy; protein phosphorylation; carbohydrate metabolic process; glycogen catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	5255
	18679
	ENSG00000067177
	ENSMUSG00000034055
	P46020
	P18826
	NM_001122670; NM_001172436; NM_002637
	NM_008832; NM_173021
	NP_001116142; NP_001165907; NP_002628
	NP_032858; NP_766609
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKA1 gene.^[5]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000067177 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034055 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PHKA1 phosphorylase kinase, alpha 1 (muscle)".

External links

GeneReviews/NCBI/NIH/UW entry on Phosphorylase Kinase Deficiency, Glycogen Storage Disease Type IX

Template:PBB Controls

This protein-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000067177 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034055 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PHKA1 phosphorylase kinase, alpha 1 (muscle)".

[1]

[2]

[3]

[4]

[5]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading

External links