TPK1

TPK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3S4Y
Identifiers
Aliases	TPK1, HPP20, THMD5, thiamin pyrophosphokinase 1
External IDs	OMIM: 606370; MGI: 1352500; HomoloGene: 6960; GeneCards: TPK1; OMA:TPK1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	144,836,395 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	43,643,212 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; monocyte; ; duodenum; ; Achilles tendon; ; blood; ; gonad; ; endothelial cell; ; testicle; ; granulocyte;
	Top expressed in
	right kidney; ; proximal tubule; ; epithelium of stomach; ; human kidney; ; pyloric antrum; ; ileum; ; duodenum; ; jejunum; ; mucous cell of stomach; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thiamine diphosphokinase activity; transferase activity; thiamine binding; nucleotide binding; ATP binding; kinase activity;
Cellular component	cytosol;
Biological process	thiamine metabolic process; thiamine diphosphate biosynthetic process; phosphorylation; thiamine-containing compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	27010
	29807
	ENSG00000196511
	ENSMUSG00000029735
	Q9H3S4
	Q9R0M5
NM_001042482; NM_022445; NM_001350879; NM_001350880; NM_001350881;
	NM_001350882; NM_001350883; NM_001350884; NM_001350885; NM_001350886; NM_001350887; NM_001350889; NM_001350893; NM_001350894; NM_001350895
	NM_013861; NM_001311111
NP_001035947; NP_071890; NP_001337808; NP_001337809; NP_001337810;
	NP_001337811; NP_001337812; NP_001337813; NP_001337814; NP_001337815; NP_001337816; NP_001337818; NP_001337822; NP_001337823; NP_001337824
	NP_001298040; NP_038889
	Wikidata
View/Edit Human	View/Edit Mouse

Thiamin pyrophosphokinase 1 is an enzyme that in humans is encoded by the TPK1 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196511 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029735 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nosaka K, Onozuka M, Kakazu N, Hibi S, Nishimura H, Nishino H, Abe T (May 2001). "Isolation and characterization of a human thiamine pyrophosphokinase cDNA". Biochim Biophys Acta. 1517 (2): 293–7. doi:10.1016/s0167-4781(00)00247-5. PMID 11342111.
^ "Entrez Gene: TPK1 thiamin pyrophosphokinase 1".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading