KvLQT1
Template:PBB Kv7.1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1.[1] Kv7.1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction.
Mutations in the gene can lead to a defective protein and several forms of inherited arrhythmias as Long QT syndrome, Short QT syndrome, and Familial Atrial Fibrillation. Currents arising from Kv7.1 in over-expression systems have never been recapitulated in native tissues - Kv7.1 is always found in native tissues with a modulatory subunit. In cardiac tissue, these subunits comprise KCNE1 and yotiao. Though physiologically irrelevant, homotetrameric Kv7.1 channels also display a unique form of N-type inactivation that reaches quilibrium quickly, allowing KvLQT1 currents to plateau. This is different from the inactivation seen in A-type currents, in which most of the current never returns.
See also
References
- ^ Jespersen T, Grunnet M, Olesen SP (2005). "The KCNQ1 potassium channel: from gene to physiological function". Physiology (Bethesda). 20: 408–16. doi:10.1152/physiol.00031.2005. PMID 16287990.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
Further reading
External links
- "Voltage-Gated Potassium Channels: Kv7.1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
{{cite web}}: Cite has empty unknown parameter:|coauthors=(help) - KVLQT1+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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