CACNB1

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CACNB1
Protein CACNB1 PDB 1t0h.png
Identifiers
Aliases CACNB1, CAB1, CACNLB1, CCHLB1, calcium voltage-gated channel auxiliary subunit beta 1
External IDs MGI: 102522 HomoloGene: 20186 GeneCards: CACNB1
RNA expression pattern
PBB GE CACNB1 206996 x at tn.png

PBB GE CACNB1 210185 at tn.png

PBB GE CACNB1 210967 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000723
NM_199247
NM_199248

RefSeq (protein)

NP_000714.3
NP_954855.1
NP_954856.1

NP_001152791.1
NP_112450.1

Location (UCSC) Chr 17: 39.17 – 39.2 Mb Chr 11: 98 – 98.02 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Voltage-dependent L-type calcium channel subunit beta-1 is a protein that in humans is encoded by the CACNB1 gene.[3][4][5]

The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Gregg RG, Powers PA, Hogan K (Mar 1993). "Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping". Genomics. 15 (1): 185–7. doi:10.1006/geno.1993.1029. PMID 8381767. 
  4. ^ Iles DE, Segers B, Sengers RC, Monsieurs K, Heytens L, Halsall PJ, Hopkins PM, Ellis FR, Hall-Curran JL, Stewart AD, et al. (Oct 1993). "Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility". Hum Mol Genet. 2 (7): 863–8. doi:10.1093/hmg/2.7.863. PMID 8395940. 
  5. ^ a b "Entrez Gene: CACNB1 calcium channel, voltage-dependent, beta 1 subunit". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.