From Wikipedia, the free encyclopedia
Jump to: navigation, search
Calcium channel, voltage-dependent, beta 1 subunit
Protein CACNB1 PDB 1t0h.png
PDB rendering based on 1t0h.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM114207 MGI102522 HomoloGene20186 GeneCards: CACNB1 Gene
RNA expression pattern
PBB GE CACNB1 210185 at tn.png
PBB GE CACNB1 206996 x at tn.png
PBB GE CACNB1 210967 x at tn.png
More reference expression data
Species Human Mouse
Entrez 782 12295
Ensembl ENSG00000067191 ENSMUSG00000020882
UniProt Q02641 Q8R3Z5
RefSeq (mRNA) NM_000723 NM_001159319
RefSeq (protein) NP_000714 NP_001152791
Location (UCSC) Chr 17:
39.17 – 39.2 Mb
Chr 11:
98 – 98.02 Mb
PubMed search [1] [2]

Voltage-dependent L-type calcium channel subunit beta-1 is a protein that in humans is encoded by the CACNB1 gene.[1][2][3]

The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[3]

See also[edit]


  1. ^ Gregg RG, Powers PA, Hogan K (Mar 1993). "Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping". Genomics 15 (1): 185–7. doi:10.1006/geno.1993.1029. PMID 8381767. 
  2. ^ Iles DE, Segers B, Sengers RC, Monsieurs K, Heytens L, Halsall PJ, Hopkins PM, Ellis FR, Hall-Curran JL, Stewart AD; et al. (Oct 1993). "Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility". Hum Mol Genet 2 (7): 863–8. doi:10.1093/hmg/2.7.863. PMID 8395940. 
  3. ^ a b "Entrez Gene: CACNB1 calcium channel, voltage-dependent, beta 1 subunit". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.