Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is a protein found primarily in skeletal muscle. In humans, it is encoded by the RYR1gene.
RYR1 functions as a calcium release channel in the sarcoplasmic reticulum, as well as a connection between the sarcoplasmic reticulum and the transverse tubule. The channel is associated with the dihydropyridine receptor of the sarcoplasmic reticulum, which opens in response to depolarization and thus effectively means that the RYR1 channel opens in response to depolarization of the cell.
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