KCNN1

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KCNN1
Identifiers
Aliases KCNN1, KCa2.1, SK1, SKCA1, hSK1, potassium calcium-activated channel subfamily N member 1
External IDs MGI: 1933993 HomoloGene: 37595 GeneCards: 3780
RNA expression pattern
PBB GE KCNN1 206231 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002248

NM_032397

RefSeq (protein)

NP_002239.2

NP_115773.2

Location (UCSC) Chr 19: 17.95 – 18 Mb Chr 8: 70.84 – 70.86 Mb
PubMed search [1] [2]
Wikidata
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Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 , also known as KCNN1 is a human gene encoding the KCa2.1 protein.[3]

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The KCa2.1 protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. The KCNN1 gene is a member of the KCNN family of potassium channel genes.[3]

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Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.