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Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
Symbols KCNN1 ; KCa2.1; SK1; SKCA1; hSK1
External IDs OMIM602982 MGI1933993 HomoloGene37595 IUPHAR: 381 ChEMBL: 2369 GeneCards: KCNN1 Gene
RNA expression pattern
PBB GE KCNN1 206231 at tn.png
More reference expression data
Species Human Mouse
Entrez 3780 84036
Ensembl ENSG00000105642 ENSMUSG00000002908
UniProt Q92952 Q9EQR3
RefSeq (mRNA) NM_002248 NM_032397
RefSeq (protein) NP_002239 NP_115773
Location (UCSC) Chr 19:
17.95 – 18 Mb
Chr 8:
70.84 – 70.86 Mb
PubMed search [1] [2]

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 , also known as KCNN1 is a human gene encoding the KCa2.1 protein.[1]

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The KCa2.1 protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. The KCNN1 gene is a member of the KCNN family of potassium channel genes.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.