CatSper3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
CATSPER3
Identifiers
Aliases CATSPER3, CACRC, CatSper3, cation channel sperm associated 3
External IDs MGI: 1924106 HomoloGene: 12658 GeneCards: CATSPER3
Targeted by Drug
alprostadil, dinoprostone, progesterone, mibefradil[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178019

NM_001252487
NM_001252488
NM_029772

RefSeq (protein)

NP_821138

NP_001239416.1
NP_084048.1
NP_001239416
NP_001239417
NP_084048

Location (UCSC) Chr 5: 134.97 – 135.01 Mb Chr 13: 55.78 – 55.81 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

CatSper3, is a protein which in humans is encoded by the CATSPER3 gene.[4][5][6][7] CatSper3 is a member of the cation channels of sperm family of proteins. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[8]

References[edit]

  1. ^ "Drugs that physically interact with Cation channel sperm associated 3 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Arias JM, Murbartián J, Perez-Reyes E (March 2003). "Cloning of a novel one-repeat calcium channel-like gene". Biochem. Biophys. Res. Commun. 303 (1): 31–6. doi:10.1016/S0006-291X(03)00276-6. PMID 12646162. 
  5. ^ Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: Characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451Freely accessible. PMID 12932298. 
  6. ^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895Freely accessible. PMID 17227845. 
  7. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. 
  8. ^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.