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Aliases CLCA2, CACC, CACC3, CLCRG2, CaCC-3, chloride channel accessory 2
External IDs MGI: 2139758 HomoloGene: 4765 GeneCards: 9635
RNA expression pattern
PBB GE CLCA2 206164 at tn.png

PBB GE CLCA2 206165 s at tn.png

PBB GE CLCA2 206166 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 86.42 – 86.46 Mb Chr 3: 145.07 – 145.1 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Chloride channel accessory 2 is a protein that in humans is encoded by the CLCA2 gene.[3]

The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.[3] Protein structure prediction methods suggest the N-terminal region of CLCA2 protein is a zinc metalloprotease.[4]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: CLCA2 chloride channel, calcium activated, family member 2". 
  4. ^ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.