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Chloride channel accessory 2
Symbols CLCA2 ; CACC; CACC3; CLCRG2; CaCC-3
External IDs OMIM604003 MGI2139758 HomoloGene4765 GeneCards: CLCA2 Gene
RNA expression pattern
PBB GE CLCA2 206165 s at tn.png
PBB GE CLCA2 206164 at tn.png
PBB GE CLCA2 206166 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9635 229933
Ensembl ENSG00000137975 ENSMUSG00000036960
UniProt Q9UQC9 Q8BG22
RefSeq (mRNA) NM_006536 NM_178697
RefSeq (protein) NP_006527 NP_848812
Location (UCSC) Chr 1:
86.42 – 86.46 Mb
Chr 3:
145.07 – 145.1 Mb
PubMed search [1] [2]

Chloride channel accessory 2 is a protein that in humans is encoded by the CLCA2 gene.[1]

The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.[1] Protein structure prediction methods suggest the N-terminal region of CLCA2 protein is a zinc metalloprotease.[2]

See also[edit]


  1. ^ a b "Entrez Gene: CLCA2 chloride channel, calcium activated, family member 2". 
  2. ^ Pawłowski K, Lepistö M, Meinander N; et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.