SCN7A

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SCN7A
Identifiers
Aliases SCN7A, NaG, Nav2.1, Nav2.2, SCN6A, sodium voltage-gated channel alpha subunit 7
External IDs MGI: 102965 HomoloGene: 55706 GeneCards: SCN7A
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SCN7A
Genomic location for SCN7A
Band 2q24.3 Start 166,403,573 bp[1]
End 166,494,247 bp[1]
RNA expression pattern
PBB GE SCN7A 207864 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002976

NM_009135

RefSeq (protein)

NP_002967

n/a

Location (UCSC) Chr 2: 166.4 – 166.49 Mb Chr 2: 66.67 – 66.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sodium channel protein type 7 subunit alpha is a protein that in humans is encoded by the SCN7A gene on the chromosome specifically located at 2q21-23 chromosome site.[5][6] This is one of 10 Sodium channel types, and is expressed in the heart, the uterus and in glial cells. Its sequence identity is 48, and it is the only sodium channel known to be completely un-blockable by TTX (tetrodotoxin).[7]


See also[edit]

Scn7a is the name of the gene that encodes to a membrane protein, in particular a Sodium Channel Nax (also known as NaG, Nav2.1, etc.) It belongs to a family of Sodium Channel known as Voltage-Gated, but is not activated by changes in the membrane's voltage, as happen usually in the members of this family (Nav1.1 to Nav1.9); it activates by changes in the extracellular concentration of sodium [~150 mM].[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136546 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034810 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Plummer NW, Meisler MH (April 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics. 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179. 
  6. ^ "Entrez Gene: SCN7A sodium channel, voltage-gated, type VII, alpha". 
  7. ^ a b Hiyama TY, Watanabe E, Ono K, Inenaga K, Tamkun MM, Yoshida S, Noda M (June 2002). "Na(x) channel involved in CNS sodium-level sensing". Nature Neuroscience. 5 (6): 511–2. doi:10.1038/nn0602-856. PMID 11992118. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.