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Sodium channel, voltage gated, type VII alpha subunit
Symbols SCN7A ; NaG; Nav2.1; Nav2.2; SCN6A
External IDs OMIM182392 MGI102965 HomoloGene55706 ChEMBL: 3585 GeneCards: SCN7A Gene
RNA expression pattern
PBB GE SCN7A 207864 at tn.png
More reference expression data
Species Human Mouse
Entrez 6332 20272
Ensembl ENSG00000136546 ENSMUSG00000034810
UniProt Q01118 B1AYL1
RefSeq (mRNA) NM_002976 NM_009135
RefSeq (protein) NP_002967 NP_033161
Location (UCSC) Chr 2:
166.4 – 166.49 Mb
Chr 2:
66.67 – 66.78 Mb
PubMed search [1] [2]

Sodium channel protein type 7 subunit alpha is a protein that in humans is encoded by the SCN7A gene on the chromosome specifically located at 2q21-23 chromosome site.[1][2] This is one of 10 Sodium channel types, and is expressed in the heart, the uterus and in glial cells. Its sequence identity is 48, and it is the only sodium channel known to be completely un-blockable by TTX (tetrodotoxin)

See also[edit]

Scn7a is the name of the gene that encodes to a membrane protein, in particular a Sodium Channel Nax (also known as NaG, Nav2.1, etc.) It belongs to a family of Sodium Channel known as Voltage-Gated, but is not activated by changes in the membrane's voltage, as happen usually in the members of this family (Nav1.1 to Nav1.9); it activates by changes in the extracellular concentration of sodium [~150 mM].


  1. ^ Plummer NW, Meisler MH (May 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179. 
  2. ^ "Entrez Gene: SCN7A sodium channel, voltage-gated, type VII, alpha". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.