Aquaporin 1

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AQP1
AQP1.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAQP1, AQP-CHIP, CHIP28, CO, aquaporin 1 (Colton blood group)
External IDsOMIM: 107776 MGI: 103201 HomoloGene: 68051 GeneCards: AQP1
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for AQP1
Genomic location for AQP1
Band7p14.3Start30,911,694 bp[1]
End30,925,517 bp[1]
RNA expression pattern
PBB GE AQP1 207542 s at fs.png

PBB GE AQP1 209047 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007472

RefSeq (protein)

NP_001316801
NP_932766

NP_031498

Location (UCSC)Chr 7: 30.91 – 30.93 MbChr 6: 55.34 – 55.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Aquaporin 1 is a protein that in humans is encoded by the AQP1 gene.

AQP1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle, and in the descending portion of the vasa recta. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, and lungs.

It is not regulated by vasopressin (ADH).

Function[edit]

Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement.[5]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000240583 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004655 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: AQP1 aquaporin 1 (Colton blood group)".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.