From Wikipedia, the free encyclopedia
Jump to: navigation, search
Transient receptor potential cation channel, subfamily M, member 5
Symbols TRPM5 ; LTRPC5; MTR1
External IDs OMIM604600 HomoloGene22818 IUPHAR: 497 ChEMBL: 1628468 GeneCards: TRPM5 Gene
Species Human Mouse
Entrez 29850 56843
Ensembl ENSG00000070985 ENSMUSG00000009246
UniProt Q9NZQ8 Q9JJH7
RefSeq (mRNA) NM_014555 NM_020277
RefSeq (protein) NP_055370 NP_064673
Location (UCSC) Chr 11:
2.4 – 2.42 Mb
Chr 7:
143.07 – 143.09 Mb
PubMed search [1] [2]

Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.[1][2]


TRPM5 is a key component of taste transduction in the gustatory system of bitter, sweet and umami tastes being activated by high levels of intracellular calcium. It has also been targeted as a possible contributor to fat taste signaling. [3] [4] The calcium dependent opening of TRPM5 produces a depolarizing generator potential which leads to an action potential.[5]

See also[edit]


  1. ^ Prawitt D, Enklaar T, Klemm G, Gärtner B, Spangenberg C, Winterpacht A, Higgins M, Pelletier J, Zabel B (January 2000). "Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression". Hum. Mol. Genet. 9 (2): 203–16. doi:10.1093/hmg/9.2.203. PMID 10607831. 
  2. ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  3. ^ PubMed
  4. ^ PubMed
  5. ^ Chaudhari N, Roper SD (August 2010). "The cell biology of taste". J. Cell Biol. 190 (3): 285–96. doi:10.1083/jcb.201003144. PMC 2922655. PMID 20696704. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.