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Aliases TRPM5, LTRPC5, MTR1, transient receptor potential cation channel subfamily M member 5
External IDs OMIM: 604600 MGI: 1861718 HomoloGene: 22818 GeneCards: TRPM5
Targeted by Drug
flufenamic acid, Hydron, spermine[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 2.4 – 2.42 Mb Chr 7: 143.07 – 143.09 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.[4][5]


TRPM5 is a key component of taste transduction in the gustatory system of bitter, sweet and umami tastes being activated by high levels of intracellular calcium. It has also been targeted as a possible contributor to fat taste signaling.[6][7] The calcium dependent opening of TRPM5 produces a depolarizing generator potential which leads to an action potential.[8]

TPRM5 is also expressed in tuft cells.

See also[edit]


  1. ^ "Drugs that physically interact with Transient receptor potential cation channel subfamily M member 5 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Prawitt D, Enklaar T, Klemm G, Gärtner B, Spangenberg C, Winterpacht A, Higgins M, Pelletier J, Zabel B (January 2000). "Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression". Hum. Mol. Genet. 9 (2): 203–16. doi:10.1093/hmg/9.2.203. PMID 10607831. 
  5. ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  6. ^ PMID 21557960
  7. ^ PMID 21653867
  8. ^ Chaudhari N, Roper SD (August 2010). "The cell biology of taste". J. Cell Biol. 190 (3): 285–96. doi:10.1083/jcb.201003144. PMC 2922655Freely accessible. PMID 20696704. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.