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Potassium channel, two pore domain subfamily K, member 7
Symbols KCNK7 ; K2p7.1; TWIK3
External IDs OMIM603940 MGI1341841 HomoloGene43131 IUPHAR: 519 GeneCards: KCNK7 Gene
Species Human Mouse
Entrez 10089 16530
Ensembl ENSG00000173338 ENSMUSG00000024936
UniProt Q9Y2U2 Q9Z2T1
RefSeq (mRNA) NM_005714 NM_001004138
RefSeq (protein) NP_005705 NP_034739
Location (UCSC) Chr 11:
65.59 – 65.6 Mb
Chr 19:
5.7 – 5.71 Mb
PubMed search [1] [2]

Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which in humans is encoded by the KCNK7 gene. K2P7.1 is a potassium channel containing two pore-forming P domains.[1][2][3] Multiple transcript variants encoding different isoforms have been found for this gene.[4]


This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.[4]

See also[edit]


  1. ^ Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M (April 1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991. 
  2. ^ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. 
  3. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. 
  4. ^ a b "Entrez Gene: potassium channel". 

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