KCNK7

From Wikipedia, the free encyclopedia
Jump to: navigation, search
KCNK7
Identifiers
Aliases KCNK7, K2p7.1, TWIK3, potassium two pore domain channel subfamily K member 7
External IDs MGI: 1341841 HomoloGene: 43131 GeneCards: KCNK7
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for KCNK7
Genomic location for KCNK7
Band 11q13.1 Start 65,592,855 bp[1]
End 65,595,996 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033456
NM_005714
NM_033347
NM_033348
NM_033455

NM_001004138
NM_010609

RefSeq (protein)

NP_005705
NP_203133
NP_203134
NP_258416

NP_034739

Location (UCSC) Chr 11: 65.59 – 65.6 Mb Chr 11: 5.7 – 5.71 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which in humans is encoded by the KCNK7 gene. K2P7.1 is a potassium channel containing two pore-forming P domains.[5][6][7] Multiple transcript variants encoding different isoforms have been found for this gene.[8]

Function[edit]

This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.[8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173338 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024936 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M (April 1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991. 
  6. ^ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. 
  7. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. 
  8. ^ a b "Entrez Gene: potassium channel". 

Further reading[edit]

External links[edit]