KCNIP2

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KCNIP2
Identifiers
Aliases KCNIP2, KCHIP2, potassium voltage-gated channel interacting protein 2
External IDs MGI: 2135916 HomoloGene: 23710 GeneCards: KCNIP2
Gene location (Human)
Chromosome 10 (human)
Chr. Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for KCNIP2
Genomic location for KCNIP2
Band 10q24.32 Start 101,825,974 bp[1]
End 101,843,920 bp[1]
RNA expression pattern
PBB GE KCNIP2 221321 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001276358
NM_030716
NM_145703
NM_145704

RefSeq (protein)

NP_001263287
NP_109641
NP_663749
NP_663750

Location (UCSC) Chr 10: 101.83 – 101.84 Mb Chr 10: 45.79 – 45.82 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kv channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the KCNIP2 gene.[5][6]

Function[edit]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120049 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025221 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–6. doi:10.1038/35000592. PMID 10676964. 
  6. ^ a b "Entrez Gene: KCNIP2 Kv channel interacting protein 2". 
  7. ^ Burgoyne RD (Mar 2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews. Neuroscience. 8 (3): 182–93. doi:10.1038/nrn2093. PMC 1887812Freely accessible. PMID 17311005. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.