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Potassium channel, subfamily K, member 1
Crystallographic structure of human TWIK-1. The gray boxes indicate approximate location of the lipid bilayer.[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KCNK1 ; DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1; TWIK1
External IDs OMIM601745 MGI109322 HomoloGene1691 IUPHAR: 513 GeneCards: KCNK1 Gene
Species Human Mouse
Entrez 3775 16525
Ensembl ENSG00000135750 ENSMUSG00000033998
UniProt O00180 O08581
RefSeq (mRNA) NM_002245 NM_008430
RefSeq (protein) NP_002236 NP_032456
Location (UCSC) Chr 1:
233.75 – 233.81 Mb
Chr 8:
126 – 126.03 Mb
PubMed search [1] [2]

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.[2][3][4]

This gene encodes K2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.[4]

See also[edit]


  1. ^ PDB: 3UKM ; Miller AN, Long SB (27 January 2012). "Crystal structure of the human two-pore domain potassium channel K2P1". Science 335 (6067): 432–6. doi:10.1126/science.1213274. PMID 22282804. 
  2. ^ Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M (Dec 1996). "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43". Genomics 34 (1): 153–5. doi:10.1006/geno.1996.0259. PMID 8661042. 
  3. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. 
  4. ^ a b "Entrez Gene: KCNK1 potassium channel, subfamily K, member 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.