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Available structures
PDBOrtholog search: PDBe RCSB
AliasesKCNK1, DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1, potassium two pore domain channel subfamily K member 1
External IDsOMIM: 601745 MGI: 109322 HomoloGene: 1691 GeneCards: KCNK1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for KCNK1
Genomic location for KCNK1
Band1q42.2Start233,614,106 bp[1]
End233,672,514 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 233.61 – 233.67 MbChr 8: 126 – 126.03 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene.[5][6][7]

This gene encodes K2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, and it may require other non-pore-forming proteins for activity.[7]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135750 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033998 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lesage F, Mattei M, Fink M, Barhanin J, Lazdunski M (Dec 1996). "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43". Genomics. 34 (1): 153–5. doi:10.1006/geno.1996.0259. PMID 8661042.
  6. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
  7. ^ a b "Entrez Gene: KCNK1 potassium channel, subfamily K, member 1".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.